A novel NF-κB activation inhibitor blocks inflammatory mediator production and disease severity in the dextran sulfate (DSS) model of mouse colitis

被引:0
|
作者
Roshak, A
Flanigan, A
Imburgia, C
Carlson, K
Marshall, LA
Callahan, J
Murthy, S
Yonchuk, J
机构
[1] GlaxoSmithKline, King Of Prussia, PA USA
[2] Med Coll Penn & Hahnemann Univ, Philadelphia, PA USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
3729
引用
收藏
页码:A690 / A690
页数:1
相关论文
共 50 条
  • [31] Anti-inflammatory effects of an ethanol extract of Aster glehni via inhibition of NF-κB activation in mice with DSS-induced colitis
    Choi, Jun-Hyeok
    Chung, Kyung-Sook
    Jin, Bo-Ram
    Cheon, Se-Yun
    Nugroho, Agung
    Roh, Seong-Soo
    An, Hyo-Jin
    FOOD & FUNCTION, 2017, 8 (07) : 2611 - 2620
  • [32] Oxidative status of mouse azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated cancer model and the effects of COX-2 inhibitor
    Kismali, Gorkem
    Uner, Aykut Gokturk
    Meral, Ogunc
    Alpay, Merve
    Cakir, Dilek Ulker
    Kosova, Funda
    Sel, Tevhide
    CANCER RESEARCH, 2016, 76
  • [33] Suppression of MAPK and NF-κ B pathways by schisandrin B contributes to attenuation of DSS-induced mice model of inflammatory bowel disease
    Li, Weidong
    Liu, Yang
    Wang, Zhi
    Yu, Ting
    Lu, Qin
    Chen, Hong
    PHARMAZIE, 2015, 70 (09): : 598 - 603
  • [34] Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation
    Sun, Yang
    Zhao, Yue
    Yao, Jing
    Zhao, Li
    Wu, Zhaoqiu
    Wang, Yu
    Pan, Di
    Miao, Hanchi
    Guo, Qinglong
    Lu, Na
    BIOCHEMICAL PHARMACOLOGY, 2015, 94 (02) : 142 - 154
  • [35] Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation
    Shin, Ji-Sun
    Yun, Kyung-Jin
    Chung, Kyung-Sook
    Seo, Kyeong-Hwa
    Park, Hee-Juhn
    Cho, Young-Wuk
    Baek, Nam-In
    Jang, DaeSik
    Lee, Kyung-Tae
    FOOD AND CHEMICAL TOXICOLOGY, 2013, 53 : 263 - 271
  • [36] Prevention of Inflammatory Activation of Human Gestational Membranes in an Ex Vivo Model Using a Pharmacological NF-κB Inhibitor
    Keelan, Jeffrey A.
    Khan, Sadiqa
    Yosaatmadja, Francisca
    Mitchell, Murray A.
    JOURNAL OF IMMUNOLOGY, 2009, 183 (08): : 5270 - 5278
  • [37] Anti-inflammatory effects of novel AP-1 and NF-B inhibitors in dextran-sulfate-sodium-induced colitis in rats
    El-Salhy, Magdy
    Umezawa, Kazuo
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 37 (06) : 1457 - 1464
  • [38] A Truncated Variant of ASCC1, a Novel Inhibitor of NF-κB, Is Associated with Disease Severity in Patients with Rheumatoid Arthritis
    Torices, Silvia
    Alvarez-Rodriguez, Lorena
    Grande, Lara
    Varela, Ignacio
    Munoz, Pedro
    Pascual, Dora
    Balsa, Alejandro
    Lopez-Hoyos, Marcos
    Martinez-Taboada, Victor
    Fernandez-Luna, Jose L.
    JOURNAL OF IMMUNOLOGY, 2015, 195 (11): : 5415 - 5420
  • [39] Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation
    Watanabe, Ryo
    Azuma, Ryoko Wakizono
    Suzuki, Jun-ichi
    Ogawa, Masahito
    Itai, Akiko
    Hirata, Yasunobu
    Komuro, Issei
    Isobe, Mitsuaki
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2013, 305 (12): : H1761 - H1771
  • [40] Acalypha australis L. Extract Attenuates DSS-Induced Ulcerative Colitis in Mice by Regulating Inflammatory Factor Release and Blocking NF-κB Activation
    Chen, Bo
    Wang, Yiqing
    Niu, YouYa
    Li, Shenghua
    JOURNAL OF MEDICINAL FOOD, 2023, 26 (09) : 663 - 671