A novel NF-κB activation inhibitor blocks inflammatory mediator production and disease severity in the dextran sulfate (DSS) model of mouse colitis

被引:0
|
作者
Roshak, A
Flanigan, A
Imburgia, C
Carlson, K
Marshall, LA
Callahan, J
Murthy, S
Yonchuk, J
机构
[1] GlaxoSmithKline, King Of Prussia, PA USA
[2] Med Coll Penn & Hahnemann Univ, Philadelphia, PA USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
3729
引用
收藏
页码:A690 / A690
页数:1
相关论文
共 50 条
  • [21] Novel compound JOAB-40 decreases inflammation in vitro and colitis severity in vivo by using the murine Dextran Sulfate Sodium (DSS) model
    Szollosi, Doreen E.
    Khajah, Maitham
    Hawai, Sanaa
    Ghoneim, Ola
    Bill, Ashley
    Daniels-Monk, Mallory
    Edafiogho, Ivan O.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [22] Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-κB and STAT3 as potential targets
    Lee, Hyung-Jun
    Lee, Hee Geum
    Choi, Ki-Seok
    Surh, Young-Joon
    Na, Hye-Kyung
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 437 (02) : 267 - 273
  • [23] Differential expression of inflammatory and fibrogenic genes and their regulation by NF-κB inhibition in a mouse model of chronic colitis
    Wu, Feng
    Chakravarti, Shukti
    JOURNAL OF IMMUNOLOGY, 2007, 179 (10): : 6988 - 7000
  • [24] Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation
    Wang, Xiaoping
    Sun, Yang
    Zhao, Yue
    Ding, Youxiang
    Zhang, Xiaobo
    Kong, Lingyi
    Li, Zhiyu
    Guo, Qinglong
    Zhao, Li
    BIOCHEMICAL PHARMACOLOGY, 2016, 106 : 70 - 81
  • [25] Anti-Inflammatory Effects of Heritiera littoralis Fruits on Dextran Sulfate Sodium- (DSS-) Induced Ulcerative Colitis in Mice by Regulating Gut Microbiota and Suppressing NF-κB Pathway
    Lin, Guosheng
    Li, Minyao
    Xu, Nan
    Wu, Xiaoli
    Liu, Jingjing
    Wu, Yulin
    Zhang, Qian
    Cai, Jian
    Gao, Changjun
    Su, Ziren
    BIOMED RESEARCH INTERNATIONAL, 2020, 2020
  • [26] Dysplasia (DYS) and cancer (Ca) in the dextran sulfate sodium (DSS) mouse colitis model: Relevance to human disease and the role of inflammation to DYS/CA
    Cooper, HS
    Murthy, S
    Kido, K
    Yoshitake, H
    Flanigan, A
    LABORATORY INVESTIGATION, 1999, 79 (01) : 73A - 73A
  • [27] Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
    Ruiz Castro, Pedro A.
    Kogel, Ulrike
    Lo Sasso, Giuseppe
    Phillips, Blaine W.
    Sewer, Alain
    Titz, Bjorn
    Garcia, Llenalia
    Kondylis, Athanasios
    Guedj, Emmanuel
    Peric, Dariusz
    Bornand, David
    Dulize, Remi
    Merg, Celine
    Corciulo, Maica
    Ivanov, Nikolai V.
    Peitsch, Manuel C.
    Hoeng, Julia
    JOURNAL OF INFLAMMATION-LONDON, 2020, 17 (01):
  • [28] Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
    Pedro A. Ruiz Castro
    Ulrike Kogel
    Giuseppe Lo Sasso
    Blaine W. Phillips
    Alain Sewer
    Bjorn Titz
    Llenalia Garcia
    Athanasios Kondylis
    Emmanuel Guedj
    Dariusz Peric
    David Bornand
    Remi Dulize
    Celine Merg
    Maica Corciulo
    Nikolai V. Ivanov
    Manuel C. Peitsch
    Julia Hoeng
    Journal of Inflammation, 17
  • [29] Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ
    Li, Ming Yue
    Zhang, Zhi Hong
    Wang, Zhe
    Zuo, Hong Xiang
    Wang, Jing Ying
    Xing, Yue
    Jin, Cheng Hua
    Xu, Guang Hua
    Piao, Lian Xun
    Ma, Juan
    Jin, Xuejun
    PHARMACOLOGICAL RESEARCH, 2019, 147
  • [30] Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice
    Li, Puze
    Wu, Minna
    Xiong, Wancheng
    Li, Jinsong
    An, Yunying
    Ren, Jie
    Xie, Yingguang
    Xue, Hongfei
    Yan, Dong
    Li, Min
    Zhong, Genshen
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 81