Blocking CRMP2 SUMOylation reverses neuropathic pain

被引:44
|
作者
Moutal, A. [1 ]
Dustrude, E. T. [1 ,4 ,5 ]
Largent-Milnes, T. M. [1 ]
Vanderah, T. W. [1 ,2 ]
Khanna, M. [1 ]
Khanna, R. [1 ,2 ,3 ]
机构
[1] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA
[2] Univ Arizona, Dept Anesthesiol, Coll Med, Tucson, AZ 85721 USA
[3] Univ Arizona, Dept Neurosci, Coll Med, Grad Interdisciplinary Program, Tucson, AZ 85721 USA
[4] Indiana Univ Sch Med, Dept Psychiat, Inst Psychiat Res, Indianapolis, IN 46202 USA
[5] Indiana Univ Sch Med, Stark Neurosci Res Inst, Neurosci Res Bldg,320W 15th St,Room 314, Indianapolis, IN 46202 USA
关键词
SCHIZOPHRENIA; GENE;
D O I
10.1038/mp.2017.117
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:2119 / 2121
页数:3
相关论文
共 50 条
  • [41] Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4
    Yamazaki, Yuki
    Nagai, Jun
    Akinaga, Satoshi
    Koga, Yumeno
    Hasegawa, Masaya
    Takahashi, Miyuki
    Yamashita, Naoya
    Kolattukudy, Papachan
    Goshima, Yoshio
    Ohshima, Toshio
    BRAIN RESEARCH, 2020, 1736
  • [42] CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration
    Morales, Xabier
    Pelaez, Rafael
    Garasa, Saray
    Ortiz de Solorzano, Carlos
    Rouzaut, Ana
    BIOMOLECULES, 2021, 11 (10)
  • [43] Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement
    Yue-Peng Jiang
    Song Wang
    Wei-Dong Lai
    Xue-Qing Wu
    Yan Jin
    Zheng-Hao Xu
    Aubin Moutal
    Rajesh Khanna
    Ki Duk Park
    Zhi-Ming Shan
    Cheng-Ping Wen
    Jie Yu
    Arthritis Research & Therapy, 24 (1)
  • [44] Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?
    Moutal, Aubin
    Khanna, Rajesh
    NEUROSCIENCE, 2018, 376 : 224 - 226
  • [45] CRMP5 Interacts with Tubulin to Inhibit Neurite Outgrowth, Thereby Modulating the Function of CRMP2
    Brot, Sebastien
    Rogemond, Veronique
    Perrot, Valerie
    Chounlamountri, Naura
    Auger, Carole
    Honnorat, Jerome
    Moradi-Ameli, Mahnaz
    JOURNAL OF NEUROSCIENCE, 2010, 30 (32): : 10639 - 10654
  • [46] Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity
    Zhongqi Zhang
    JiFeng Zhang
    Jiong Li
    Jiaqi Zhang
    Li Chen
    Yalan Li
    Guoqing Guo
    Journal of Molecular Neuroscience, 2020, 70 : 353 - 364
  • [47] Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency
    Saitoh, Fuminori
    Hagiwara, Hiroko
    Wakatsuki, Shuji
    Araki, Toshiyuki
    NEUROSCIENCE RESEARCH, 2019, 139 : 58 - 62
  • [48] Molecular dynamics simulations and in vitro analysis of the CRMP2 thiol switch
    Moeller, Daniel
    Gellert, Manuela
    Langel, Walter
    Lillig, Christopher Horst
    MOLECULAR BIOSYSTEMS, 2017, 13 (09) : 1744 - 1753
  • [49] Redox control of cytoskeletal dynamics: toggling the thiol switch in CRMP2
    Gellert, M.
    Berndt, C.
    Deponte, M.
    Lillig, C. H.
    FEBS JOURNAL, 2015, 282 : 115 - 115
  • [50] Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity
    Zhang, Zhongqi
    Zhang, JiFeng
    Li, Jiong
    Zhang, Jiaqi
    Chen, Li
    Li, Yalan
    Guo, Guoqing
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2020, 70 (03) : 353 - 364