Blocking CRMP2 SUMOylation reverses neuropathic pain

被引：44
|
作者：
Moutal, A. [1 ]
Dustrude, E. T. [1 ,4 ,5 ]
Largent-Milnes, T. M. [1 ]
Vanderah, T. W. [1 ,2 ]
Khanna, M. [1 ]
Khanna, R. [1 ,2 ,3 ]
机构：
[1] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA
[2] Univ Arizona, Dept Anesthesiol, Coll Med, Tucson, AZ 85721 USA
[3] Univ Arizona, Dept Neurosci, Coll Med, Grad Interdisciplinary Program, Tucson, AZ 85721 USA
[4] Indiana Univ Sch Med, Dept Psychiat, Inst Psychiat Res, Indianapolis, IN 46202 USA
[5] Indiana Univ Sch Med, Stark Neurosci Res Inst, Neurosci Res Bldg,320W 15th St,Room 314, Indianapolis, IN 46202 USA
来源：
MOLECULAR PSYCHIATRY | 2018年 / 23卷 / 11期
关键词：
SCHIZOPHRENIA; GENE;
D O I：
10.1038/mp.2017.117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：2119 / 2121
页数：3
相关论文
共 50 条
  • [31] TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
    Flávio Henrique Pequeno de Macedo
    Rosária Dias Aires
    Esdras Guedes Fonseca
    Renata Cristina Mendes Ferreira
    Daniel Portela Dias Machado
    Lina Chen
    Fang-Xiong Zhang
    Ivana A. Souza
    Virgínia Soares Lemos
    Thiago Roberto Lima Romero
    Aubin Moutal
    Rajesh Khanna
    Gerald W. Zamponi
    Jader S. Cruz
    Molecular Brain, 12
  • [32] CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain
    Guo, Youjia
    Oliveros, Carolina Fiallos
    Ohshima, Toshio
    DEVELOPMENTAL NEUROBIOLOGY, 2022, 82 (06) : 533 - 544
  • [33] Distinct roles of CRMP1 and CRMP2 within growth cones in axon growth
    Higurashi, Masakazu
    Iketani, Masumi
    Takei, Kohtaro
    Yamashita, Naoya
    Kawahara, Nobutaka
    Goshima, Yoshio
    NEUROSCIENCE RESEARCH, 2011, 71 : E236 - E236
  • [34] TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
    Pequeno de Macedo, Flavio Henrique
    Aires, Rosaria Dias
    Fonseca, Esdras Guedes
    Mendes Ferreira, Renata Cristina
    Dias Machado, Daniel Portela
    Chen, Lina
    Zhang, Fang-Xiong
    Souza, Ivana A.
    Lemos, Virginia Soares
    Lima Romero, Thiago Roberto
    Moutal, Aubin
    Khanna, Rajesh
    Zamponi, Gerald W.
    Cruz, Jader S.
    MOLECULAR BRAIN, 2019, 12 (01)
  • [35] Localized role of CRMP1 and CRMP2 in neurite outgrowth and growth cone steering
    Higurashi, Masakazu
    Iketani, Masumi
    Takei, Kohtaro
    Yamashita, Naoya
    Aoki, Reina
    Kawahara, Nobutaka
    Goshima, Yoshio
    DEVELOPMENTAL NEUROBIOLOGY, 2012, 72 (12) : 1528 - 1540
  • [36] Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2
    Zhu, Ling-Qiang
    Zheng, Hong-Yun
    Peng, Cai-Xia
    Liu, Dan
    Li, Hong-Lian
    Wang, Qun
    Wang, Jian-Zhi
    JOURNAL OF NEUROSCIENCE, 2010, 30 (10): : 3839 - 3848
  • [37] CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons
    Brustovetsky, Tatiana
    Khanna, Rajesh
    Brustovetsky, Nickolay
    CELLS, 2021, 10 (10)
  • [38] Molecular mechanism of axon guidance mediated by phosphorylation of CRMP2
    Uchida, Y
    Goshima, Y
    SEIKAGAKU, 2005, 77 (11): : 1424 - 1427
  • [39] Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement
    Jiang, Yue-Peng
    Wang, Song
    Lai, Wei-Dong
    Wu, Xue-Qing
    Jin, Yan
    Xu, Zheng-Hao
    Moutal, Aubin
    Khanna, Rajesh
    Park, Ki Duk
    Shan, Zhi-Ming
    Wen, Cheng-Ping
    Yu, Jie
    ARTHRITIS RESEARCH & THERAPY, 2022, 24 (01)
  • [40] CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons
    Liu, Zhi-Zhi
    Zhu, Jian
    Wang, Chang-Ling
    Wang, Xin
    Han, Ying-Ying
    Liu, Ling-Yan
    Xu, Hong A.
    NEURAL PLASTICITY, 2018, 2018
12345