Blocking CRMP2 SUMOylation reverses neuropathic pain

被引:44
|
作者
Moutal, A. [1 ]
Dustrude, E. T. [1 ,4 ,5 ]
Largent-Milnes, T. M. [1 ]
Vanderah, T. W. [1 ,2 ]
Khanna, M. [1 ]
Khanna, R. [1 ,2 ,3 ]
机构
[1] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA
[2] Univ Arizona, Dept Anesthesiol, Coll Med, Tucson, AZ 85721 USA
[3] Univ Arizona, Dept Neurosci, Coll Med, Grad Interdisciplinary Program, Tucson, AZ 85721 USA
[4] Indiana Univ Sch Med, Dept Psychiat, Inst Psychiat Res, Indianapolis, IN 46202 USA
[5] Indiana Univ Sch Med, Stark Neurosci Res Inst, Neurosci Res Bldg,320W 15th St,Room 314, Indianapolis, IN 46202 USA
关键词
SCHIZOPHRENIA; GENE;
D O I
10.1038/mp.2017.117
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:2119 / 2121
页数:3
相关论文
共 50 条
  • [1] Blocking CRMP2 SUMOylation reverses neuropathic pain
    A Moutal
    E T Dustrude
    T M Largent-Milnes
    T W Vanderah
    M Khanna
    R Khanna
    Molecular Psychiatry, 2018, 23 : 2119 - 2121
  • [2] SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons
    Ju, Weina
    Li, Qi
    Wilson, Sarah M.
    Brittain, Joel M.
    Meroueh, Louay
    Khanna, Rajesh
    CHANNELS, 2013, 7 (03) : 153 - 159
  • [3] Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines
    Zhang, Jifeng
    Zhao, Bo
    Zhu, Xiaonan
    Li, Jiong
    Wu, Fengming
    Li, Sumei
    Gong, Xiaobing
    Cha, Caihui
    Guo, Guoqing
    BRAIN RESEARCH BULLETIN, 2018, 139 : 21 - 30
  • [4] Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain
    Moutal, Aubin
    Cai, Song
    Yu, Jie
    Stratton, Harrison J.
    Chefdeville, Aude
    Gomez, Kimberly
    Ran, Dongzhi
    Madura, Cynthia L.
    Boinon, Lisa
    Soto, Maira
    Zhou, Yuan
    Shan, Zhiming
    Chew, Lindsey A.
    Rodgers, Kathleen E.
    Khanna, Rajesh
    PAIN, 2020, 161 (11) : 2629 - 2651
  • [5] CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking
    Dustrude, Erik T.
    Wilson, Sarah M.
    Ju, Weina
    Xiao, Yucheng
    Khanna, Rajesh
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (34) : 24316 - 24331
  • [6] Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential
    Xie, Jennifer Y.
    Chew, Lindsey A.
    Yang, Xiaofang
    Wang, Yuying
    Qu, Chaoling
    Wang, Yue
    Federici, Lauren M.
    Fitz, Stephanie D.
    Ripsch, Matthew S.
    Due, Michael R.
    Moutal, Aubin
    Khanna, May
    White, Fletcher A.
    Vanderah, Todd W.
    Johnson, Philip L.
    Porreca, Frank
    Khanna, Rajesh
    PAIN, 2016, 157 (09) : 2124 - 2140
  • [7] Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides
    Feldman, Polina
    Khanna, Rajesh
    NEUROSCIENCE LETTERS, 2013, 557 : 27 - 36
  • [8] Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief
    Moutal, Aubin
    Shan, Zhiming
    Miranda, Victor G.
    Francois-Moutal, Liberty
    Madura, Cynthia L.
    Khanna, May
    Khanna, Rajesh
    CHANNELS, 2019, 13 (01) : 498 - 504
  • [9] CRMP2 is necessary for Neurofibromatosis type 1 related pain
    Moutal, Aubin
    Cai, Song
    Luo, Shizhen
    Voisin, Raphaelle
    Khanna, Rajesh
    CHANNELS, 2018, 12 (01) : 47 - 50
  • [10] Inhibition of Ubc9-Induced CRMP2 SUMOylation Disrupts Glioblastoma Cell Proliferation
    Wang, Leilei
    Ji, Suzhen
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2019, 69 (03) : 391 - 398