Quencher-free molecular beacon: Enhancement of the signal-to-background ratio with graphene oxide

被引：25
|
作者：
Yi, Jeong Wu [2 ]
Park, Jaesung [1 ]
Singh, N. Jiten [1 ]
Lee, Il Joon [2 ]
Kim, Kwang S. [1 ]
Kim, Byeang Hyean [2 ]
机构：
[1] Pohang Univ Sci & Technol, BK Sch Mol Sci, Dept Chem, Ctr Superfunct Mat, Pohang, South Korea
[2] Pohang Univ Sci & Technol, BK Sch Mol Sci, Dept Chem, Lab Modified Nucle Acid Syst, Pohang 790784, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 02期
关键词：
Quencher-free molecular beacon; Molecular beacon; Graphene oxide; Signal-to-background ratio; Fluorescence; NUCLEIC-ACIDS; DNA; FILMS; FLUORESCENCE; PLATFORM; SHEETS; STEM;
D O I：
10.1016/j.bmcl.2010.12.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report the highly improved version of quencher-free molecular beacon (QF-MB) system by using graphene oxide (GO) as an external quencher. This QF-MB/GO system provided a higher S/B ratio (31,0) relative to that (2,2) of the same system in the absence of GO, while retaining a high selectivity for fully matched over single-base-mismatched targets. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：704 / 706
页数：3
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