Quencher-free molecular beacon: Enhancement of the signal-to-background ratio with graphene oxide

被引：25

作者：

Yi, Jeong Wu ^{[2
]}

Park, Jaesung ^{[1
]}

Singh, N. Jiten ^{[1
]}

Lee, Il Joon ^{[2
]}

Kim, Kwang S. ^{[1
]}

Kim, Byeang Hyean ^{[2
]}

机构：

[1] Pohang Univ Sci & Technol, BK Sch Mol Sci, Dept Chem, Ctr Superfunct Mat, Pohang, South Korea

[2] Pohang Univ Sci & Technol, BK Sch Mol Sci, Dept Chem, Lab Modified Nucle Acid Syst, Pohang 790784, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 02期

关键词：

Quencher-free molecular beacon; Molecular beacon; Graphene oxide; Signal-to-background ratio; Fluorescence; NUCLEIC-ACIDS; DNA; FILMS; FLUORESCENCE; PLATFORM; SHEETS; STEM;

D O I：

10.1016/j.bmcl.2010.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the highly improved version of quencher-free molecular beacon (QF-MB) system by using graphene oxide (GO) as an external quencher. This QF-MB/GO system provided a higher S/B ratio (31,0) relative to that (2,2) of the same system in the absence of GO, while retaining a high selectivity for fully matched over single-base-mismatched targets. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：704 / 706

页数：3

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