Urinary metabolites of daidzin orally administered in rats

被引：0
|
作者：
Yasuda, T [1 ]
Ohsawa, K [1 ]
机构：
[1] Tohoku Coll Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9818558, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1998年 / 21卷 / 09期
关键词：
daidzin; Puerariae lobata OHWI; urinary metabolite; 3; 4; 7-trihydroxyisoflavone; 7-dihydroxyisoflavanone; equol;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In a study on the metabolism of flavonoids, the isoflavone glycoside daidzin was orally administered to rats. Urine samples were collected and treated,with beta-glucuronidase and arylsulfatase. Aglycone daidzein (M3) and other three metabolites, 3',4',7-trihydroxyisoflavone (M1), 4',7-dihydroxyisoflavanone (M2) and 4',7-dihydroxyisoflavan (M4) were isolated from the urine following treatment with enzymes. The structures of M1, M2 and M4 were determined on the basis of chemical and spectral data.
引用
收藏
页码：953 / 957
页数：5
相关论文
共 50 条
  • [41] Identification of urinary metabolites in rats administered the fluorine-containing pyrethroids metofluthrin, profluthrin, and transfluthrin
    Yoshida, Toshiaki
    TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, 2012, 94 (09): : 1789 - 1804
  • [42] EFFECT OF ORALLY ADMINISTERED GESTAGEN ON ANAPHYLACTIC REACTIONS IN RATS
    SZONTAGH, FE
    FOLDI, M
    VARGA, L
    BARDOCZY, A
    JOURNAL OF ENDOCRINOLOGY, 1964, 28 (02) : 159 - &
  • [43] Antioxidant status of rats administered silver nanoparticles orally
    Adeyemi, Oluyomi Stephen
    Faniyan, Temiloluwa Oluwashindara
    JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES, 2014, 9 (03): : 182 - 186
  • [44] Developmental toxicity of orally administered technical dimethoate in rats
    Farag, AT
    Karkour, TAZ
    El Okazy, A
    BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 2006, 77 (01) : 40 - 46
  • [45] Disposition of orally and intravenously administered methyltetrahydrofuran in rats and mice
    Henderson, Rogene F.
    Gurule, Mark
    Hedtke-Weber, Briana M.
    Ghanbari, Katayoon
    McDonald, Jacob D.
    Kracko, Dean A.
    Dix, Kelly J.
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2007, 70 (07): : 582 - 593
  • [46] ACUTE TOXICITY OF CHOLINE CHLORIDE ADMINISTERED ORALLY TO RATS
    NEUMAN, MW
    HODGE, HC
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1945, 58 (01): : 87 - 88
  • [47] BIODISTRIBUTION AND METABOLISM OF ORALLY-ADMINISTERED OCTACOSANOL IN RATS
    KABIR, Y
    KIMURA, S
    ANNALS OF NUTRITION AND METABOLISM, 1993, 37 (01) : 33 - 38
  • [48] Study on the developmental toxicity of orally administered isobutylidenediurea in rats
    Hellwig, J
    Klimisch, HJ
    BethHubner, M
    FOOD AND CHEMICAL TOXICOLOGY, 1997, 35 (07) : 677 - 681
  • [49] Pharmacokinetics of chitobiose and chitotriose administered intravenously or orally to rats
    Chen, AS
    Taguchi, T
    Okamoto, H
    Danjo, K
    Sakai, K
    Matahira, Y
    Wang, MW
    Miwa, I
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (03) : 545 - 548
  • [50] Pharmacokinetic Studies of Orally Administered Magnesium Oxide in Rats
    Yoshimura, Yuya
    Fujisaki, Kosuke
    Yamamoto, Takenori
    Shinohara, Yasuo
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2017, 137 (05): : 581 - 587
12345