Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers

被引：20

作者：

Kim, Ki-Hyun ^{[2
]}

Lee, Jong-Chan ^{[2
]}

Lee, Jonghwi ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Chem Engn & Mat Sci, Seoul 156756, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

来源：

MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 04期

关键词：

drug-delivery systems; micelles; non-linear polymers; particle size distribution; water-soluble polymers;

D O I：

10.1002/mabi.200700161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximate to 10(-8) m) than for conventional. surfactants and block copolymers.

引用

页码：339 / 346

页数：8

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