Synthesis and characterization of novel amphiphilic polymers as drug delivery nano carriers

被引:14
|
作者
Pandey, Mukesh K. [1 ,2 ]
Tyagi, Rahul [1 ,2 ]
Gupta, Bhavna [1 ,2 ]
Parmar, Virinder S. [1 ,2 ,3 ]
Kumar, Jayant [1 ,2 ]
Watterson, Arthur C. [1 ,2 ]
机构
[1] Univ Massachusetts Lowell, Inst Nanosci & Engn Technol, Lowell, MA USA
[2] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA USA
[3] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India
关键词
encapsulation; self-assembly; amphiphilic polymer; nano-particles; drug delivery; chemo-enzymatic; Novozyme-435; Candida antarctica lipase B; static light scattering; micelles;
D O I
10.1080/10601320802380158
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Polymer nano-particles have been widely investigated in the last decade due to a variety of potential applications. In particular, polymers which can self assemble into micellar nano-particles can be effectively used as vehicles for drug delivery. Considerable efforts are underway to develop better drug delivery nano carriers for high drug loading capacity for a wide variety of bioactive compounds. In this study, several new polymers were synthesized in bulk (solventless condition) by a chemo-enzymatic methodology using Candida antarctica lipase B (Novozyme 435) and molecular sieves (MS). The synthesized polymers demonstrated high drug loading capacity and the potential to encapsulate drugs which are poorly soluble in aqueous solvents.
引用
收藏
页码:931 / 937
页数:7
相关论文
共 50 条
  • [1] Synthesis of amphiphilic guanylated polymers as potential gene delivery carriers
    Sharma, SK
    Sharma, AK
    Samuelson, LA
    Kumar, J
    Watterson, AC
    Parmar, VS
    [J]. JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2004, A41 (12): : 1459 - 1466
  • [2] Synthesis, characterization and effects of arm number on properties of amphiphilic polyurethanes as drug delivery carriers
    Wang, Shihai
    Zhou, Yu
    Zhuang, Bo
    Chen, Hongxiang
    Wang, Lijuan
    Huang, Dengcheng
    Zou, Tao
    [J]. JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, 2017, 54 (11): : 765 - 771
  • [3] Synthesis and characterization of dendritic star-shaped zwitterionic polymers as novel anticancer drug delivery carriers
    Li, Lina
    Wang, Yan
    Ji, Feng
    Wen, Yan
    Li, Junjie
    Yang, Boguang
    Yao, Fanglian
    [J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2014, 25 (14-15) : 1641 - 1657
  • [4] Characterization of novel soybean-oil-based thermosensitive amphiphilic polymers for drug delivery applications
    Abdekhodaie, Mohammad J.
    Liu, Zengshe
    Erhan, Sevim Z.
    Wu, Xiao Yu
    [J]. POLYMER INTERNATIONAL, 2012, 61 (09) : 1477 - 1484
  • [5] Synthesis and Characterization of Amphiphilic Lipopolymers for Micellar Drug Delivery
    Li, Feng
    Danquah, Michael
    Mahato, Ram I.
    [J]. BIOMACROMOLECULES, 2010, 11 (10) : 2610 - 2620
  • [6] Synthesis, characterization, and evaluation of differently sulfonated resins as novel carriers for drug delivery
    Doraswamy, K.
    Ramana, P. Venkata
    [J]. DESIGNED MONOMERS AND POLYMERS, 2013, 16 (01) : 56 - 66
  • [7] Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics
    Salim, Malinda
    Minamikawa, Hiroyuki
    Sugimura, Akihiko
    Hashim, Rauzah
    [J]. MEDCHEMCOMM, 2014, 5 (11) : 1602 - 1618
  • [8] The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery
    Clare, Hoskins
    Lin, Paul Kong Thoo
    Tetley, Laurence
    Cheng, Woei Ping
    [J]. PHARMACEUTICAL RESEARCH, 2012, 29 (03) : 782 - 794
  • [9] Novel PEGylated Amphiphilic Copolymers as Nanocarriers for Drug Delivery: Synthesis, Characterization and Curcumin Encapsulation
    Kumar, Vijayendra
    Gupta, Bhavna
    Kumar, Gaurav
    Pandey, Mukesh K.
    Aiazian, Eric
    Parmar, Virinder S.
    Kumar, Jayant
    Watterson, Arthur C.
    [J]. JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, 2010, 47 (12): : 1154 - 1160
  • [10] The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery
    Hoskins Clare
    Paul Kong Thoo Lin
    Laurence Tetley
    Woei Ping Cheng
    [J]. Pharmaceutical Research, 2012, 29 : 782 - 794