Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers

被引：20
|
作者：
Kim, Ki-Hyun [2 ]
Lee, Jong-Chan [2 ]
Lee, Jonghwi [1 ]
机构：
[1] Chung Ang Univ, Dept Chem Engn & Mat Sci, Seoul 156756, South Korea
[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea
来源：
MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 04期
关键词：
drug-delivery systems; micelles; non-linear polymers; particle size distribution; water-soluble polymers;
D O I：
10.1002/mabi.200700161
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximate to 10(-8) m) than for conventional. surfactants and block copolymers.
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页码：339 / 346
页数：8
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