Image quality phantom and parameters for high spatial resolution small-animal SPECT

被引：8
|
作者：
Visser, Eric P. [1 ]
Harteveld, Anita A. [2 ]
Meeuwis, Antoi P. W. [1 ]
Disselhorst, Jonathan A. [1 ]
Beekman, Freek J. [3 ,4 ]
Oyen, Wim J. G. [1 ]
Boerman, Otto C. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Nucl Med, NL-6500 HB Nijmegen, Netherlands
[2] Univ Twente, Inst Tech Med, NL-7500 AE Enschede, Netherlands
[3] Delft Univ Technol, Sect Radiat Detect & Med Imaging, Delft, Netherlands
[4] Mol Imaging Labs, Utrecht, Netherlands
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2011年 / 654卷 / 01期
关键词：
SPECT; Small animal; Image quality; NEMA; Phantom; PINHOLE SPECT; PET SCANNER; RECONSTRUCTION; COLLIMATION; TOMOGRAPHY; DEVICE; SYSTEM; CT;
D O I：
10.1016/j.nima.2011.06.036
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
At present, generally accepted standards to characterize small-animal single photon emission tomographs (SPECT) do not exist. Whereas for small-animal positron emission tomography (PET), the NEMA NU 4-2008 guidelines are available, such standards are still lacking for small-animal SPECT. More specifically, a dedicated image quality (IQ) phantom and corresponding IQ parameters are absent. The structures of the existing PET IQ phantom are too large to fully characterize the sub-millimeter spatial resolution of modern multi-pinhole SPECT scanners, and its diameter will not fit into all scanners when operating in high spatial resolution mode. We therefore designed and constructed an adapted IQ phantom with smaller internal structures and external diameter, and a facility to guarantee complete filling of the smallest rods. The associated IQ parameters were adapted from NEMA NU 4. An additional parameter, effective whole-body sensitivity, was defined since this was considered relevant in view of the variable size of the field of view and the use of multiple bed positions as encountered in modern small-animal SPECT scanners. The usefulness of the phantom was demonstrated for (99m)Tc in a USPECT-II scanner operated in whole-body scanning mode using a multi-pinhole mouse collimator with 0.6 mm pinhole diameter. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：539 / 545
页数：7
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