Investigation of SP1 and SP3 Expressions in Colorectal Cancer Carcinogenesis

The study aimed to determine the expressions of SP1 and SP3 and the clinical-pathological characteristics of patients, and the correlation between the expressions of Specificity Protein 1 (SP1) and Specificity Protein 3 (SP3) in colorectal cancer (CRC). In this study, tumour and adjacent non-tumour tissue samples were obtained from 41 individuals with CRC. SP1 and SP3 expressions were performed using Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR). According to the results of our study, there was no statistically significant difference in SP1 and SP3 expression levels between tumour tissues and non-tumour tissues (p>0.05), as well as no association with clinicalpathological features of patients. In addition, a high positive correlation was found between the expressions of SP1 and SP3 genes in CRC (p=0.01). Consequently, it can be said that there is a correlation between SP1 and SP3 expressions, but SP1 and SP3 expressions are not related to CRC carcinogenesis.