Investigation of SP1 and SP3 Expressions in Colorectal Cancer Carcinogenesis

被引：0

作者：

Gurer, Turkan ^{[1
]}

Al-Doori, Ibrahim ^{[1
]}

Aytekin, Alper ^{[2
]}

Mihcioglu, Deniz ^{[3
]}

机构：

[1] Gaziantep Univ, Fac Art & Sci, Dept Biol, TR-27310 Gaziantep, Turkey

[2] Gaziantep Univ, Sch Med, Dept Gen Surg, TR-27310 Gaziantep, Turkey

[3] SANKO Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-27090 Gaziantep, Turkey

来源：

INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2021年 / 21卷 / 03期

关键词：

Colorectal Tumour; Gene Expression; Specificity Protein 1; Specificity Protein 3; Transcription Factors; TRANSCRIPTION FACTOR SP1; GENE-EXPRESSION; SURVIVAL; LEADS;

D O I：

10.31901/24566330.2021/21.03.777

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The study aimed to determine the expressions of SP1 and SP3 and the clinical-pathological characteristics of patients, and the correlation between the expressions of Specificity Protein 1 (SP1) and Specificity Protein 3 (SP3) in colorectal cancer (CRC). In this study, tumour and adjacent non-tumour tissue samples were obtained from 41 individuals with CRC. SP1 and SP3 expressions were performed using Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR). According to the results of our study, there was no statistically significant difference in SP1 and SP3 expression levels between tumour tissues and non-tumour tissues (p>0.05), as well as no association with clinicalpathological features of patients. In addition, a high positive correlation was found between the expressions of SP1 and SP3 genes in CRC (p=0.01). Consequently, it can be said that there is a correlation between SP1 and SP3 expressions, but SP1 and SP3 expressions are not related to CRC carcinogenesis.

引用

页码：137 / 143

页数：7

共 50 条

[31] 趋势升级，支持Windows Vista SP1及XP SP3
微电脑世界, 2008, (05) : 177 - 177
[32] Sp1 and Sp3 regulate human asparagine synthetase gene expression.
Pineda, VL
Kilberg, MS
FASEB JOURNAL, 2002, 16 (04): : A262 - A263
[33] Sp1 and Sp3 regulate transcription of the chicken GAS41 gene
Huebner, Katrin
Phi-van, Loc
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2010, 1799 (5-6): : 442 - 447
[34] Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3
Pan, L
Glenn, ST
Jones, CA
Gronostajski, RM
Gross, KW
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2003, 1625 (03): : 280 - 290
[35] Binding of Sp1/Sp3 to the proximal promoter of the hMOR gene is enhanced by DAMGO
Xu, YH
Carr, LG
GENE, 2001, 274 (1-2) : 119 - 128
[36] Transcription of the LAT gene is regulated by multiple binding sites for Sp1 and Sp3
Whitten, Caitlyn
Swygert, Sarah
Butler, Sara E.
Finco, Timothy S.
GENE, 2008, 413 (1-2) : 58 - 66
[37] Sp1 and sp3 are important regulators of AP-2γ gene transcription
Li, M
Kellems, RE
BIOLOGY OF REPRODUCTION, 2003, 69 (04) : 1220 - 1230
[38] Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms
Thakur, Bhupesh Kumar
Dasgupta, Nirmalya
Ta, Atri
Das, Santasabuj
NUCLEIC ACIDS RESEARCH, 2016, 44 (12) : 5658 - 5672
[39] Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells
Hedrick, Erik
Cheng, Yating
Jin, Un-Ho
Kim, Kyounghyun
Safe, Stephen
ONCOTARGET, 2016, 7 (16) : 22245 - 22256
[40] Regulation of CYP4B1 lung specific expression by Sp1 and Sp3
Poch, MT
Yost, GS
Hines, RN
FASEB JOURNAL, 2004, 18 (04): : A239 - A240

← 1 2 3 4 5 →