Investigation of SP1 and SP3 Expressions in Colorectal Cancer Carcinogenesis

被引：0
|
作者：
Gurer, Turkan [1 ]
Al-Doori, Ibrahim [1 ]
Aytekin, Alper [2 ]
Mihcioglu, Deniz [3 ]
机构：
[1] Gaziantep Univ, Fac Art & Sci, Dept Biol, TR-27310 Gaziantep, Turkey
[2] Gaziantep Univ, Sch Med, Dept Gen Surg, TR-27310 Gaziantep, Turkey
[3] SANKO Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-27090 Gaziantep, Turkey
来源：
INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2021年 / 21卷 / 03期
关键词：
Colorectal Tumour; Gene Expression; Specificity Protein 1; Specificity Protein 3; Transcription Factors; TRANSCRIPTION FACTOR SP1; GENE-EXPRESSION; SURVIVAL; LEADS;
D O I：
10.31901/24566330.2021/21.03.777
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The study aimed to determine the expressions of SP1 and SP3 and the clinical-pathological characteristics of patients, and the correlation between the expressions of Specificity Protein 1 (SP1) and Specificity Protein 3 (SP3) in colorectal cancer (CRC). In this study, tumour and adjacent non-tumour tissue samples were obtained from 41 individuals with CRC. SP1 and SP3 expressions were performed using Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR). According to the results of our study, there was no statistically significant difference in SP1 and SP3 expression levels between tumour tissues and non-tumour tissues (p>0.05), as well as no association with clinicalpathological features of patients. In addition, a high positive correlation was found between the expressions of SP1 and SP3 genes in CRC (p=0.01). Consequently, it can be said that there is a correlation between SP1 and SP3 expressions, but SP1 and SP3 expressions are not related to CRC carcinogenesis.
引用
收藏
页码：137 / 143
页数：7
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