The ideas of variable sampling interval (VSI), variable sample size (VSS), variable sample size and sampling interval (VSSI), and variable parameters (VP) in the univariate case have been successfully applied to the multivariate case to improve the efficiency of Hotelling's T-2 chart with fixed sampling rate (FSR) in detecting small process shifts. However, the main disadvantage in using most of these control schemes is an increasing in the complexity due to the adaptive changes in sampling intervals. In this paper, retaining the lengths of sampling intervals constant, a variable sample size and control limit (VSSC) T-2 chart is proposed and described. The statistical efficiency of the VSSC T-2 chart in terms of the average time to signal a shift in process mean vector is compared with that of the VP, VSSI, VSS, VSI, and FSR T-2 charts. From the results of comparison, it shows that the VSSC T-2 chart for a (very) small shift in the process mean vector gives a better performance than the VSSI, VSS, VSI, and FSR T-2 charts; meanwhile, it presents a similar performance to the VP T-2 chart. Furthermore, from the viewpoint of practicability, it is more convenient for administrating the control chart than the VSI, VSSI, and VP T-2 chart. Thus, it may provide a good option for quick response to small shifts in a multivariate process. (c) 2006 Elsevier B.V. All rights reserved.