Practical Pd(TFA)2-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions

被引：3
|
作者：
Yu, Yang [1 ,2 ]
Mang, Zhiguo [1 ,2 ]
Yang, Wei [3 ]
Li, Hao [1 ,2 ]
Wang, Wei [1 ,2 ,4 ]
机构：
[1] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China
[3] Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[4] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
来源：
CATALYSTS | 2016年 / 6卷 / 11期
基金：
美国国家科学基金会;
关键词：
Pd(TFA)(2); 4+1] annulation; alpha-alkenyl-dicarbonyl compounds; unprotected primary amines; one-pot; tandem reaction; regio-selective; N BOND FORMATION; WACKER-TYPE CYCLIZATION; C-H AMIDATION; ATORVASTATIN CALCIUM; SUBSTITUTED PYRROLES; OXIDATIVE AMINATION; EFFICIENT SYNTHESIS; 3+2 CYCLOADDITION; DERIVATIVES; ALKENES;
D O I：
10.3390/catal6110169
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The Pd(TFA)(2)-catalyzed [4+1] annulation of chained or cyclic alpha-alkenyl-dicarbonyl compounds and unprotected primary amines for "one-pot" synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O-2 as the terminal oxidant under mild conditions. In addition, this method was applied to synthesize highly regioselective aminomethylated and di(1H-pyrrol-3-yl) methane products.
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页数：11
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