Practical Pd(TFA)2-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions

被引：3

作者：

Yu, Yang ^{[1
,2
]}

Mang, Zhiguo ^{[1
,2
]}

Yang, Wei ^{[3
]}

Li, Hao ^{[1
,2
]}

Wang, Wei ^{[1
,2
,4
]}

机构：

[1] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China

[3] Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[4] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

来源：

CATALYSTS | 2016年 / 6卷 / 11期

基金：

美国国家科学基金会;

关键词：

Pd(TFA)(2); 4+1] annulation; alpha-alkenyl-dicarbonyl compounds; unprotected primary amines; one-pot; tandem reaction; regio-selective; N BOND FORMATION; WACKER-TYPE CYCLIZATION; C-H AMIDATION; ATORVASTATIN CALCIUM; SUBSTITUTED PYRROLES; OXIDATIVE AMINATION; EFFICIENT SYNTHESIS; 3+2 CYCLOADDITION; DERIVATIVES; ALKENES;

D O I：

10.3390/catal6110169

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The Pd(TFA)(2)-catalyzed [4+1] annulation of chained or cyclic alpha-alkenyl-dicarbonyl compounds and unprotected primary amines for "one-pot" synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O-2 as the terminal oxidant under mild conditions. In addition, this method was applied to synthesize highly regioselective aminomethylated and di(1H-pyrrol-3-yl) methane products.

引用

页数：11

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