One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

被引：9
|
作者：
Tian, Yulin [1 ,2 ,3 ]
Qi, Jianguo [2 ,3 ]
Sun, Chenbin [2 ,3 ]
Yin, Dali [1 ,2 ,3 ]
Wang, Xiaojian [1 ,2 ,3 ]
Xiao, Qiong [2 ,3 ]
机构：
[1] Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Drugabil Ev, Dept Med Chem, Beijing 100050, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 42期
基金：
中国国家自然科学基金;
关键词：
SPONGE CORTICIUM-SIMPLEX; STEROIDAL ALKALOIDS; 3,4-DISUBSTITUTED ISOQUINOLINES; ARYLPIPERAZINE DERIVATIVES; ASYMMETRIC-SYNTHESIS; INTERNAL ALKYNES; ORGANIC HALIDES; EFFICIENT; PYRIDINES; LIGANDS;
D O I：
10.1039/c3ob41680a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.
引用
收藏
页码：7262 / 7266
页数：5
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