One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

被引：9

作者：

Tian, Yulin ^{[1
,2
,3
]}

Qi, Jianguo ^{[2
,3
]}

Sun, Chenbin ^{[2
,3
]}

Yin, Dali ^{[1
,2
,3
]}

Wang, Xiaojian ^{[1
,2
,3
]}

Xiao, Qiong ^{[2
,3
]}

机构：

[1] Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Drugabil Ev, Dept Med Chem, Beijing 100050, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 42期

基金：

中国国家自然科学基金;

关键词：

SPONGE CORTICIUM-SIMPLEX; STEROIDAL ALKALOIDS; 3,4-DISUBSTITUTED ISOQUINOLINES; ARYLPIPERAZINE DERIVATIVES; ASYMMETRIC-SYNTHESIS; INTERNAL ALKYNES; ORGANIC HALIDES; EFFICIENT; PYRIDINES; LIGANDS;

D O I：

10.1039/c3ob41680a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.

引用

页码：7262 / 7266

页数：5

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