Efficacy of the novel fungal Cyp51 inhibitor VT-1161 against invasive candidiasis caused by resistant Candida albicans

被引:0
|
作者
Najvar, L. K. [1 ,2 ]
Wiederhold, N. P. [1 ,3 ]
Garvey, E. P. [4 ]
Hoekstra, W. J. [4 ]
Moore, W. R. [4 ]
Schotzinger, R. J. [4 ]
Bocanegra, R. A. [1 ,2 ]
Kirkpatrick, W. R. [1 ,2 ]
Patterson, T. F. [1 ,2 ]
机构
[1] UTHSCSA, San Antonio, TX USA
[2] STVHCS, San Antonio, TX USA
[3] UT Austin, Austin, TX USA
[4] Viamet Pharmaceut Inc, Morrisville, NC USA
关键词
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
引用
收藏
页码:106 / 106
页数:1
相关论文
共 45 条
  • [1] The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme
    Warrilow, A. G. S.
    Hull, C. M.
    Parker, J. E.
    Garvey, E. P.
    Hoekstra, W. J.
    Moore, W. R.
    Schotzinger, R. J.
    Kelly, D. E.
    Kelly, S. L.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (12) : 7121 - 7127
  • [2] VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans
    Break, Timothy J.
    Desai, Jigar V.
    Natarajan, Mukil
    Ferre, Elise M. N.
    Henderson, Christina
    Zelazny, Adrian M.
    Siebenlist, Ulrich
    Hoekstra, William J.
    Schotzinger, Robert J.
    Garvey, Edward P.
    Lionakis, Michail S.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (01) : 151 - 155
  • [3] To evaluate the efficacy and safety of VT-1161, a potent, highly selective inhibitor of fungal CYP51, in treating women with a documented history of recurrent vulvovaginal candidiasis (RVVC)
    Brand, S.
    Degenhardt, T.
    Nyirjesy, P.
    Sobel, J.
    Handelsman, C.
    Person, K.
    Schotzinger, R.
    Tavakkol, A.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016, 215 (06) : 821 - 821
  • [4] A Preliminary Evaluation on the Antifungal Efficacy of VT-1161 against Persister Candida albicans Cells in Vulvovaginal Candidiasis
    Sinoca, Marica
    Maione, Angela
    Gambino, Edvige
    Imparato, Marianna
    Galdiero, Marilena
    de Alteriis, Elisabetta
    Galdiero, Emilia
    Guida, Marco
    [J]. BIOMEDICINES, 2024, 12 (02)
  • [5] Efficacy of the Clinical Agent VT-1161 against Fluconazole-Sensitive and -Resistant Candida albicans in a Murine Model of Vaginal Candidiasis
    Garvey, E. P.
    Hoekstra, W. J.
    Schotzinger, R. J.
    Sobel, J. D.
    Lilly, E. A.
    Fidel, P. L., Jr.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (09) : 5567 - 5573
  • [6] Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds
    Schell, W. A.
    Jones, A. M.
    Garvey, E. P.
    Hoekstra, W. J.
    Schotzinger, R. J.
    Alexander, B. D.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (03)
  • [7] The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51
    Warrilow, Andrew G. S.
    Parker, Josie E.
    Price, Claire L.
    Garvey, Edward P.
    Hoekstra, William J.
    Schotzinger, Robert J.
    Wiederhold, Nathan P.
    Nes, W. David
    Kelly, Diane E.
    Kelly, Steven L.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (07)
  • [8] NANOEMULSION FORMULATION OF A NEW CANDIDA ALBICANS CYP51 INHIBITOR
    Schoubben, Aurelie
    Cenci, Elio
    Schiaffella, Fausto
    Blasi, Paolo
    Milanese, Lara
    Rossi, Carlo
    Vecchiarelli, Anna
    Ricci, Maurizio
    Fringuelli, Renata
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 38 (01) : 126 - 127
  • [9] Susceptibility testing of VT-1129, a novel fungal CYP51 inhibitor, against Cryptococcus neoformans and Cryptococcus gattii
    Lockhart, S. R.
    Iqbal, N.
    Bolden, C. B.
    Grossman, N. T.
    Ottinger, E. A.
    Garvey, E. P.
    Brand, S. R.
    Hoekstra, W. J.
    Moore, W. R.
    Schotzinger, R. J.
    [J]. MYCOSES, 2014, 57 : 43 - 43
  • [10] In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans
    Nishimoto, Andrew T.
    Wiederhold, Nathan P.
    Flowers, Stephanie A.
    Zhang, Qing
    Kelly, Steven L.
    Morschhaeuser, Joachim
    Yates, Christopher M.
    Hoekstra, William J.
    Schotzinger, Robert J.
    Garvey, Edward P.
    Rogers, P. David
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (06)