Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds

被引：2

作者：

Schell, W. A. ^{[1
]}

Jones, A. M. ^{[1
]}

Garvey, E. P. ^{[2
]}

Hoekstra, W. J. ^{[2
]}

Schotzinger, R. J. ^{[2
]}

Alexander, B. D. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA

[2] Viamet Pharmaceut Inc, Durham, NC USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 03期

关键词：

Candida glabrata; Candida krusei; antifungal susceptibility testing; resistance; SURVEILLANCE NETWORK TRANSNET; TRANSPLANT RECIPIENTS; SUSCEPTIBILITY; INFECTIONS; EFFICACY; ALBICANS; MODEL;

D O I：

10.1128/AAC.01817-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of fungal CYP51 inhibitors VT-1161 and VT-1129 were determined for Candida glabrata (n = 34) and C. krusei (n= 50). C. glabrata isolates were screened for FKS gene mutations. All isolates were resistant clinically and/or in vitro to at least one standard antifungal compound. VT-1161 and VT-1129 MICs for all isolates were at least 5-fold below achievable human plasma levels for VT-1161. VT-1161 and VT-1129 are promising for the treatment of resistant C. glabrata and C. krusei infections.

引用

页数：3

共 3 条

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[3] In vitro activities of the novel investigational tetrazoles VT-1598 and VT-1161 against azole-resistant strains and clinical isolates of C. albicans
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[J]. MEDICAL MYCOLOGY, 2018, 56 : S102 - S102

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