Efficacy of the novel fungal Cyp51 inhibitor VT-1161 against invasive candidiasis caused by resistant Candida albicans

被引：0
|
作者：
Najvar, L. K. [1 ,2 ]
Wiederhold, N. P. [1 ,3 ]
Garvey, E. P. [4 ]
Hoekstra, W. J. [4 ]
Moore, W. R. [4 ]
Schotzinger, R. J. [4 ]
Bocanegra, R. A. [1 ,2 ]
Kirkpatrick, W. R. [1 ,2 ]
Patterson, T. F. [1 ,2 ]
机构：
[1] UTHSCSA, San Antonio, TX USA
[2] STVHCS, San Antonio, TX USA
[3] UT Austin, Austin, TX USA
[4] Viamet Pharmaceut Inc, Morrisville, NC USA
来源：
MYCOSES | 2012年 / 55卷
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页码：106 / 106
页数：1
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    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (11) : 5438 - 5447
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    Ivanchina, Natalia V.
    Dmitrenok, Pavel S.
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    Gilep, Andrei A.
    Ivanov, Alexis S.
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    Kudo, M
    Asai, K
    Okonogi, K
    Horiuchi, T
    Gotoh, O
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    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 379 (01) : 170 - 171
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    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (09) : 4151 - 4163
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    [J]. FRONTIERS IN MEDICAL TECHNOLOGY, 2022, 4
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