[1] Univ Fed Santa Catarina, Postgrad Program Med Sci, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Sao Paulo, Med Sch Hosp, BR-05508 Sao Paulo, Brazil
[3] Univ Fed Santa Catarina, Dept Internal Med, BR-88040900 Florianopolis, SC, Brazil
[4] Univ Mississippi, Sch Med, Jackson, MS 39216 USA
[5] Tufts Univ, Sch Med, Boston, MA 02111 USA
[6] Indiana Univ, Sch Med, Indianapolis, IN USA
[7] Lilly Res Labs, Indianapolis, IN USA