Resveratrol Alleviates Skeletal Muscle Insulin Resistance by Downregulating Long Noncoding RNA
被引:12
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作者:
Liu, Zhihong
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Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050051, Hebei, Peoples R China
Hebei Med Univ, Dept Endocrinol, Second Hosp, Shijiazhuang 050000, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Liu, Zhihong
[1
,2
,3
]
Zhang, Zhimei
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Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Zhang, Zhimei
[1
,2
]
Song, Guangyao
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机构:
Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Song, Guangyao
[1
,2
]
Wang, Xing
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机构:
Hebei Gen Hosp, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Wang, Xing
[4
]
Xing, Hanying
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Hebei Gen Hosp, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Xing, Hanying
[4
]
Wang, Chao
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Hebei Gen Hosp, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Wang, Chao
[4
]
机构:
[1] Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
[2] Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050051, Hebei, Peoples R China
[3] Hebei Med Univ, Dept Endocrinol, Second Hosp, Shijiazhuang 050000, Hebei, Peoples R China
[4] Hebei Gen Hosp, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R China
Long noncoding RNA (lncRNA) is a crucial factor in the progression of insulin resistance (IR). Resveratrol (RSV) exhibits promising therapeutic potential for IR. However, there are few studies on whether RSV improves IR through lncRNA. This study aimed to determine whether RSV could influence the expression of lncRNA and to elucidate the underlying mechanism. Mice were divided into three groups: control group, high-fat diet (HFD) group, and HFD + RSV group. We conducted a high-throughput sequencing analysis to detect lncRNA and mRNA expression signatures and the ceRNA-network in the skeletal muscles of mice that were fed an HFD to induce IR. Hierarchical clustering, gene enrichment, and gene ceRNA-network analyses were subsequently conducted. Differentially expressed lncRNAs were selected and validated via reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The biological functions of the selected lncRNAs were investigated by silencing the target genes via lentivirus transfection of C2C12 mouse myotube cells. RSV treatment reversed the expression of 338 mRNAs and 629 lncRNAs in the skeletal muscles of mice with HFD-induced IR. The results of the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes database analyses indicated that the differentially expressed mRNAs modulated type II diabetes mellitus. After validating randomly selected lncRNAs via RT-qPCR, we identified a novel lncRNA, NONMMUT044897.2, which was upregulated in the HFD group and reversed with RSV treatment. Additionally, NONMMUT044897.2 was proven to function as a ceRNA of microRNA- (miR-) 7051-5p. Suppressor of Cytokine Signaling 1 (SOCS1) was confirmed as a target of miR-7051-5p. We further performed lentivirus transfection to knock down NONMMUT044897.2 in vitro and found that NONMMUT044897.2 silenced SOCS1 and potentiated the insulin signaling pathway. Hence, RSV mimicked the silencing effect of lentivirus transfection on NONMMUT044897.2. Our study revealed that RSV reduced IR in mouse skeletal muscles via the regulation of NONMMUT044897.2.
机构:
Univ Maryland, Sch Med, Dept Med, VA Res Serv,Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA
VA Maryland Hlth Care Syst, Baltimore VA Med Ctr, Geriatr Res Educ & Clin Ctr GRECC, Baltimore, MD 21201 USAUniv Maryland, Sch Med, Dept Med, VA Res Serv,Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA
Ryan, Alice S.
Hafer-Macko, Charlene
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VA Maryland Hlth Care Syst, Baltimore VA Med Ctr, Geriatr Res Educ & Clin Ctr GRECC, Baltimore, MD 21201 USAUniv Maryland, Sch Med, Dept Med, VA Res Serv,Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA
Hafer-Macko, Charlene
Ortmeyer, Heidi K.
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Univ Maryland, Sch Med, Dept Med, VA Res Serv,Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA
VA Maryland Hlth Care Syst, Baltimore VA Med Ctr, Geriatr Res Educ & Clin Ctr GRECC, Baltimore, MD 21201 USAUniv Maryland, Sch Med, Dept Med, VA Res Serv,Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA
机构:
Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China
Sin, Thomas K.
Yung, Benjamin Y.
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Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China
Yung, Benjamin Y.
Siu, Parco M.
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Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R ChinaHong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China
机构:
Chinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R China
Zhang, Zong-Kang
Zhang, Ning
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Chinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R China
Zhang, Ning
Yao, Shanshan
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Chinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R China
Yao, Shanshan
Jiang, Hewen
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Chinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R China
Jiang, Hewen
Zhang, Ge
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机构:
Hong Kong Baptist Univ, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R China
Zhang, Ge
Zhang, Bao-Ting
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Chinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Sch Chinese Med, Fac Med, Hong Kong, Peoples R China
机构:
Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Endocrinol Dept, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Shu, Linyi
Hou, Guangsen
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机构:
Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Endocrinol Dept, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hou, Guangsen
Zhao, Hang
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Hebei Gen Hosp, Endocrinol Dept, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Zhao, Hang
Huang, Wenli
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机构:
Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Endocrinol Dept, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Huang, Wenli
Song, Guangyao
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机构:
Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Endocrinol Dept, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Song, Guangyao
Ma, Huijuan
论文数: 0引用数: 0
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机构:
Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China
Hebei Gen Hosp, Endocrinol Dept, 348 Heping West Rd, Shijiazhuang 050051, Hebei, Peoples R China
Hebei Gen Hosp, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R ChinaHebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China