One-pot copper-catalyzed three-component reaction: a modular approach to functionalized 2-quinolones

被引：7

作者：

Kim, Ah Reum ^{[1
,2
]}

Lim, Hee Nam ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Ecofriendly New Mat Res Ctr, Therapeut & Biotechnol Div, 141 Gajeong Ro, Daejeon 34114, South Korea

[2] Korea Univ, Dept Chem, 145 Anam Ro, Seoul 02841, South Korea

来源：

RSC ADVANCES | 2020年 / 10卷 / 13期

基金：

新加坡国家研究基金会;

关键词：

C-C; COUPLING REACTIONS; DIAMINE LIGANDS; N-ARYLATION; DERIVATIVES; ACTIVATION; ANNULATION; AMIDATION; RECEPTOR; QUINOLINONES;

D O I：

10.1039/d0ra01352h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed three-component annulation for the synthesis of functionalized 2-quinolones was developed. Three reactions including an S(N)2, a Knoevenagel, and finally C-N bond formation are involved in the designed cascade reaction using 2-bromoacylarenes, 2-iodoacetamide, and nucleophiles as the three components. A new catalytic system was discovered during the study and this modular approach is highly efficient to access functionalized 2-quinolone derivatives, compatible with a broad range of functional groups, scalable, and step-economic. Further derivatization of the obtained product demonstrates the synthetic utility of this method.

引用

页码：7855 / 7866

页数：12

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