Heterogeneous Copper-Catalyzed Cascade Three-Component Reaction Towards Imidazo[1,2-a]pyridines: Efficient and Practical One-Pot Synthesis of Alpidem

被引：11

作者：

Liao, Yang ^{[1
,2
]}

Huang, Bin ^{[1
,2
]}

Huang, Xue ^{[1
,2
]}

Cai, Mingzhong ^{[1
,2
]}

机构：

[1] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China

[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Copper; Three-component reaction; MCM-41; Imidazo[1,2-a]pyridine; Heterogeneous catalysis; HIGHLY EFFICIENT; C-N; MULTICOMPONENT REACTIONS; COUPLING REACTIONS; TERMINAL ALKYNES; DIRECT ARYLATION; PHOSPHINE-FREE; ARYL IODIDES; LIGAND-FREE; METAL-FREE;

D O I：

10.1002/slct.201900128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The heterogeneous cascade three-component reaction of 2-aminopyridines, aldehydes and terminal alkynes was achieved in toluene at 120 degrees C in the presence of 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(I) complex [MCM-41-2 N-CuCl] (5 mol%) and copper(II) complex [MCM-41-2N-Cu(OTf)(2)] (5 mol%), yielding a wide variety of imidazo[1,2-a]pyridines in mostly good to excellent yields. These two heterogeneous copper catalysts can be facilely prepared via a simple procedure from readily available and inexpensive reagents, and recovered by filtration and recycled up to eight times with almost consistent activity.

引用

页码：2320 / 2326

页数：7

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