Antituberculous activity of norfloxacin Mannich bases with isatin derivatives

被引：50

作者：

Pandeya, SN ^{[1
]}

Sriram, D

Yogeeswari, P

Ananthan, S

机构：

[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

[2] So Res Inst, TAACF, NIAID, Birmingham, AL 35255 USA

来源：

CHEMOTHERAPY | 2001年 / 47卷 / 04期

关键词：

isatin; norfloxacin; Mannich bases; antituberculous;

D O I：

10.1159/000048533

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

pounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 mug/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The lower than 6.25 mug/ml.

引用

页码：266 / 269

页数：4

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