Antituberculous activity of norfloxacin Mannich bases with isatin derivatives

被引：50
|
作者：
Pandeya, SN [1 ]
Sriram, D
Yogeeswari, P
Ananthan, S
机构：
[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
[2] So Res Inst, TAACF, NIAID, Birmingham, AL 35255 USA
来源：
CHEMOTHERAPY | 2001年 / 47卷 / 04期
关键词：
isatin; norfloxacin; Mannich bases; antituberculous;
D O I：
10.1159/000048533
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
pounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 mug/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The lower than 6.25 mug/ml.
引用
收藏
页码：266 / 269
页数：4
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