Antituberculous activity of norfloxacin Mannich bases with isatin derivatives

被引：50
|
作者：
Pandeya, SN [1 ]
Sriram, D
Yogeeswari, P
Ananthan, S
机构：
[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
[2] So Res Inst, TAACF, NIAID, Birmingham, AL 35255 USA
来源：
CHEMOTHERAPY | 2001年 / 47卷 / 04期
关键词：
isatin; norfloxacin; Mannich bases; antituberculous;
D O I：
10.1159/000048533
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
pounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv at 12.5 mug/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The lower than 6.25 mug/ml.
引用
收藏
页码：266 / 269
页数：4
相关论文
共 50 条
  • [31] Adsorption and inhibitive properties of some new Mannich bases of Isatin derivatives on corrosion of mild steel in acidic media
    Ahamad, Ishtiaque
    Prasad, Rajendra
    Quraishi, M. A.
    CORROSION SCIENCE, 2010, 52 (04) : 1472 - 1481
  • [32] Synthesis and antibacterial activity of Mannich bases of umbelliferone derivatives .4.
    Gadre, JN
    Khare, VM
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 5 (03) : 225 - 226
  • [33] ANTIVIRAL, ANTIBACTERIAL, AND ANTIFUNGAL ACTIVITIES OF ISATIN N-MANNICH BASES
    VARMA, RS
    NOBLES, WL
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (05) : 881 - 882
  • [34] ANTITUBERCULOUS ACTIVITY OF GUANIDINE DERIVATIVES
    MALYUGA, OA
    GALANOVA, RY
    PETRENKO, GM
    MUKHINA, NA
    SEMUKHIN.GV
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1971, 5 (03): : 12 - &
  • [35] Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
    Ozgun, Dilan Ozmen
    Yamali, Cem
    Gul, Halise Inci
    Taslimi, Parham
    Gulcin, Ilhami
    Yanik, Telat
    Supuran, Claudiu T.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 (06) : 1498 - 1501
  • [36] EFFECTS OF ISATIN N-MANNICH BASES ON HELA-CELLS
    MAYSINGER, D
    BAN, J
    MOVRIN, M
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 1980, 30-1 (06): : 932 - 935
  • [37] Synthesis and Antiepileptic Activity of Schiff's Bases of Dialkylamino Alkoxy Isatin Derivatives
    Swathi, Konda
    Sarangapani, Manda
    GENEDIS 2014: NEURODEGENERATION, 2015, 822 : 119 - 128
  • [38] Synthesis, Anti-inflammatory and Antioxidant Activity of Mannich Bases of Dehydrozingerone Derivatives
    Hayun, Hayun
    Arrahman, Arif
    Purwati, Euis Maras
    Yanuar, Arry
    Fortunata, Fransisca
    Suhargo, Freddyhan
    Syafiqah, Discka Winda
    Ignacia, Carissa
    Novalia, Agnes Rebecca
    JOURNAL OF YOUNG PHARMACISTS, 2018, 10 (02) : S6 - S10
  • [39] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF MANNICH-BASES OF UMBELLIFERONE DERIVATIVES .2.
    GADRE, JN
    RAOTE, PS
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1993, 32 (12): : 1285 - 1287
  • [40] BENZO[B]THIOPHENE DERIVATIVES .V. MANNICH BASES WITH ANTIMICROBIAL ACTIVITY
    CAMPAIGNE, E
    WEINBERG, ED
    CARLSON, G
    NEISS, ES
    JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (01) : 136 - +
12345