Solid-phase synthesis of peptide-derived enantiospecific nucleic acid analogs

被引：8
|
作者：
Shah, VJ
Cerpa, R
Kuntz, ID
Kenyon, GL
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,GRAD GRP BIOPHYS,SAN FRANCISCO,CA 94143
来源：
BIOORGANIC CHEMISTRY | 1996年 / 24卷 / 02期
关键词：
D O I：
10.1006/bioo.1996.0018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N-9-adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (T-m) data obtained by hybridization experiments demonstrated that these PDNAs can anneal to their complementary nucleic acid strand dT(10). (C) 1996 Academic Press, Inc.
引用
收藏
页码：201 / 206
页数：6
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