Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles

被引：25

作者：

Wang, Ting ^{[1
]}

Danishefsky, Samuel J. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab Bioorgan Chem, New York, NY 10065 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 29期

基金：

美国国家卫生研究院;

关键词：

CARBOXYLIC-ACIDS; PROTEIN-SYNTHESIS; CHEMICAL-SYNTHESIS; GENERAL-SOLUTION; OXYTOCIN; LIGATION; THIOACIDS; ROUTE;

D O I：

10.1073/pnas.1310431110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The synthesis of polypeptides on solid phase via mediation by isonitriles is described. The acyl donor is a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mixed anhydride intermediate. Applications of this chemistry to reiterative solid-phase peptide synthesis as well as solid-phase fragment coupling are described.

引用

页码：11708 / 11713

页数：6

共 50 条

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