Bradykinin in solid-phase peptide synthesis

被引:1
|
作者
Stewart, John M. [1 ]
机构
[1] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Genet, Denver, CO 80206 USA
关键词
bradykinin; solid phase peptide; synthesis;
D O I
10.1007/s10989-006-9043-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; BK) occupies a special place in the history of the development of solid-phase peptide synthesis (SPPS). It was the first biologically-active peptide to be synthesized by Merrifield using the new method. Since that time many hundreds of BK analogs have been synthesized by SPPS. Certain of these analogs show potential as drug candidates.
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页码:3 / 5
页数:3
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