A General Direct Arylation of Polyfluoroarenes with Heteroaryl and Aryl Chlorides Catalyzed by Palladium Indolylphosphine Complexes

被引：21

作者：

Yuen, On Ying ^{[1
,2
]}

Charoensak, Mueangkaew ^{[3
,4
]}

So, Chau Ming ^{[1
,2
]}

Kuhakarn, Chutima ^{[3
,4
]}

Kwong, Fuk Yee ^{[1
,2
]}

机构：

[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

[3] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[4] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem PERCH CIC, Bangkok 10400, Thailand

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2015年 / 10卷 / 04期

关键词：

aryl chlorides; CH arylation; palladium; phosphine; polyfluoroarenes; CROSS-COUPLING REACTIONS; ELECTRON-DEFICIENT POLYFLUOROARENES; PHOSPHINE-LIGANDS; MESYLATES; HALIDES; HETEROCYCLES; PRECATALYST; SELECTIVITY; ACTIVATION; DISCOVERY;

D O I：

10.1002/asia.201500048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)(2) associated with 3-(dicyclohexylphosphino)-2-phenylindole L1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non-activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1mol% Pd can be achieved.

引用

页码：857 / 861

页数：5

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