A General Direct Arylation of Polyfluoroarenes with Heteroaryl and Aryl Chlorides Catalyzed by Palladium Indolylphosphine Complexes

被引：21
|
作者：
Yuen, On Ying [1 ,2 ]
Charoensak, Mueangkaew [3 ,4 ]
So, Chau Ming [1 ,2 ]
Kuhakarn, Chutima [3 ,4 ]
Kwong, Fuk Yee [1 ,2 ]
机构：
[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
[3] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand
[4] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem PERCH CIC, Bangkok 10400, Thailand
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2015年 / 10卷 / 04期
关键词：
aryl chlorides; CH arylation; palladium; phosphine; polyfluoroarenes; CROSS-COUPLING REACTIONS; ELECTRON-DEFICIENT POLYFLUOROARENES; PHOSPHINE-LIGANDS; MESYLATES; HALIDES; HETEROCYCLES; PRECATALYST; SELECTIVITY; ACTIVATION; DISCOVERY;
D O I：
10.1002/asia.201500048
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)(2) associated with 3-(dicyclohexylphosphino)-2-phenylindole L1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non-activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1mol% Pd can be achieved.
引用
收藏
页码：857 / 861
页数：5
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