Golden beam data for proton pencil-beam scanning

被引:80
|
作者
Clasie, Benjamin [1 ,2 ]
Depauw, Nicolas [1 ,2 ]
Fransen, Maurice [1 ,2 ,3 ]
Goma, Carles [1 ,2 ]
Panahandeh, Hamid Reza [1 ,2 ]
Seco, Joao [1 ,2 ]
Flanz, Jacob B. [1 ,2 ]
Kooy, Hanne M. [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Eindhoven Univ Technol, Dept Appl Phys, NL-5600 MB Eindhoven, Netherlands
来源
PHYSICS IN MEDICINE AND BIOLOGY | 2012年 / 57卷 / 05期
关键词
SIMULATIONS; ALGORITHM; DESIGN; NOZZLE;
D O I
10.1088/0031-9155/57/5/1147
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Proton, as well as other ion, beams applied by electro-magnetic deflection in pencil-beam scanning (PBS) are minimally perturbed and thus can be quantified a priori by their fundamental interactions in a medium. This a priori quantification permits an optimal reduction of characterizing measurements on a particular PBS delivery system. The combination of a priori quantification and measurements will then suffice to fully describe the physical interactions necessary for treatment planning purposes. We consider, for proton beams, these interactions and derive a 'Golden' beam data set. The Golden beam data set quantifies the pristine Bragg peak depth-dose distribution in terms of primary, multiple Coulomb scatter, and secondary, nuclear scatter, components. The set reduces the required measurements on a PBS delivery system to the measurement of energy spread and initial phase space as a function of energy. The depth doses are described in absolute units of Gy(RBE) mm(2) Gp(-1), where Gp equals 10(9) (giga) protons, thus providing a direct mapping from treatment planning parameters to integrated beam current. We used these Golden beam data on our PBS delivery systems and demonstrated that they yield absolute dosimetry well within clinical tolerance.
引用
收藏
页码:1147 / 1158
页数:12
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