Effect of homocysteine on bone mineral density of rats

被引：8

作者：

Soyupek, Feray ^{[1
]}

Cerci, Sureyya

Yidiz, Sedat

Yildiz, Mustafa

Gurnus, Burcin

机构：

[1] Suleyman Demirel Univ, Sch Med, Dept Phys Med & Rehabil, TR-32260 Isparta, Turkey

[2] Suleyman Demirel Univ, Sch Med, Dept Nucl Med, Isparta, Turkey

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2007年 / 118卷 / 03期

关键词：

homocysteine; bone; mineral density; rats; methionine;

D O I：

10.1007/s12011-007-0034-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) L-methionine the mean plasma levels of Hey were 7.67+/-1.25 and 61.2+/-11.4 mu mol/l, respectively. Only rats treated with the higher dose had Hey levels significantly higher than those of controls, 6.38+/-0.90 mu mol/l (p<0.001). Dual Energy X-ray Absotptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hey (p<0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.

引用

页码：255 / 259

页数：5

共 50 条

[41] Effect of prepubertal ovariohysterectomy on bone mineral density and bone mineral content in puppies
Ekici, H
Sontas, BH
Toydemir, TSF
Senmevsim, Ö
Kabasakal, L
Imre, Y
ACTA VETERINARIA HUNGARICA, 2005, 53 (04) : 469 - 478
[42] Effect of different sport activities on bone mineral density and bone mineral content
Bertini, K
Andreoli, A
Melchiorri, G
De Lorenzo, A
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2000, 439 (05): : R272 - R272
[43] Relationship of homocysteine and homocysteine-related vitamins to bone mineral density in Japanese patients with type 2 diabetes
Yamada, Chizumi
Fujimoto, Shimpei
Ikeda, Kaori
Nomura, Yuki
Matsubara, Ami
Kanno, Miwako
Shide, Kenichiro
Tanaka, Kiyoshi
Imai, Eri
Fukuwatari, Tsutomu
Shibata, Katsumi
Inagaki, Nobuya
JOURNAL OF DIABETES INVESTIGATION, 2011, 2 (03) : 233 - 239
[44] Bone mineral density of alveolar bone in rats during pregnancy and lactation
Shoji, K
Ohtsuka-Isoya, M
Horiuchi, H
Shinoda, H
JOURNAL OF PERIODONTOLOGY, 2000, 71 (07) : 1073 - 1078
[45] Speed of sound, bone mineral density and bone strength in ooforectomized rats
Calero, JA
Curiel, MD
Moro, MJ
Carrascal, MT
Santana, JSR
Avial, MR
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2000, 30 (03) : 210 - 214
[46] Effects of atorvastatin on bone metabolism and bone mineral density in Wistar rats
Chang, Baocheng
Yang, Juhong
Li, Hechao
Lu, Shan
Chen, Liming
Fang, Peihua
PHARMAZIE, 2011, 66 (07): : 535 - 537
[47] Effect of Raloxifene on Arthritis and Bone Mineral Density in Rats with Collagen-Induced Arthritis
Ikuta Hayashi
Hiroshi Hagino
Toru Okano
Makoto Enokida
Ryota Teshima
Calcified Tissue International, 2011, 88 : 87 - 95
[48] Effect of Dietary Taurine and Arginine Supplementation on Bone Mineral Density in Growing Female Rats
Choi, Mi-Ja
Chang, Kyung Ja
TAURINE 8, VOL 2: NUTRITION AND METABOLISM, PROTECTIVE ROLE, AND ROLE IN REPRODUCTION, DEVELOPMENT, AND DIFFERENTIATION, 2013, 776 : 335 - 345
[49] Protective effect of Glycyrrhiza glabra roots extract on bone mineral density of ovariectomized rats
Galanis, Dimitrios
Soultanis, Konstantinos
Lelovas, Pavlos
Zervas, Alexandros
Papadopoulos, Panagiotis
Galanos, Antonis
Argyropoulou, Katerina
Makropoulou, Maria
Patsaki, Anastasia
Passali, Christina
Tsingotjidou, Anastasia
Kourkoulis, Stavros
Mitakou, Sofia
Dontas, Ismene
BIOMEDICINE-TAIWAN, 2019, 9 (02): : 2 - 12
[50] Effect of calcium supplementation combined with fucoidan and chitooligisaccaride on bone mineral density in ovariectomized rats
Kim, Mi-Hyun
Yun, Sunju
Kang, Myung-Hwa
Choi, Mi-Kyeong
Lee, Jung Dae
Jang, Ki-Hyo
Sohn, Eun Hwa
FASEB JOURNAL, 2010, 24

← 1 2 3 4 5 →