Effect of homocysteine on bone mineral density of rats

被引：8
|
作者：
Soyupek, Feray [1 ]
Cerci, Sureyya
Yidiz, Sedat
Yildiz, Mustafa
Gurnus, Burcin
机构：
[1] Suleyman Demirel Univ, Sch Med, Dept Phys Med & Rehabil, TR-32260 Isparta, Turkey
[2] Suleyman Demirel Univ, Sch Med, Dept Nucl Med, Isparta, Turkey
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2007年 / 118卷 / 03期
关键词：
homocysteine; bone; mineral density; rats; methionine;
D O I：
10.1007/s12011-007-0034-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) L-methionine the mean plasma levels of Hey were 7.67+/-1.25 and 61.2+/-11.4 mu mol/l, respectively. Only rats treated with the higher dose had Hey levels significantly higher than those of controls, 6.38+/-0.90 mu mol/l (p<0.001). Dual Energy X-ray Absotptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hey (p<0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.
引用
收藏
页码：255 / 259
页数：5
相关论文
共 50 条
  • [21] Effect of photobiomodulation therapy with different wavelengths on bone mineral density in osteoporotic rats
    Abbas Shokri
    Hanyeh Moradhaseli
    Reza Fekrazad
    Mina Jazaeri
    Maryam Farhadian
    Lasers in Medical Science, 38
  • [22] Effect of Cimicifuga extract on blood biochemistry and bone mineral density in osteoporosis rats
    Li Chunmei
    Liu Zhifeng
    Li Min
    Li Guisheng
    Liu Ke
    OSTEOPOROSIS INTERNATIONAL, 2006, 17 : 420 - 420
  • [23] Effect of photobiomodulation therapy with different wavelengths on bone mineral density in osteoporotic rats
    Shokri, Abbas
    Moradhaseli, Hanyeh
    Fekrazad, Reza
    Jazaeri, Mina
    Farhadian, Maryam
    LASERS IN MEDICAL SCIENCE, 2023, 38 (01)
  • [24] THE POSITIVE EFFECT OF MUD-BATHS ON BONE MINERAL DENSITY IN MALE RATS
    Zivna, H.
    Maric, L.
    Palicka, V.
    Hermanova, I.
    Zivny, P.
    OSTEOPOROSIS INTERNATIONAL, 2010, 21 : 306 - 307
  • [25] Synergistic effect of the pesticides toxaphene and dieldrin on bone mineral density in rats.
    Syversen, U
    Waldrun, HL
    Slordahl, KW
    Chen, D
    JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 : S451 - S451
  • [26] The effect of testosterone itself and in combination with letrozole on bone mineral density in male rats
    Saki, Forough
    Kasaee, Seyed Reza
    Sadeghian, Faezeh
    Talezadeh, Pedram
    Omrani, Gholam Hossein Ranjbar
    JOURNAL OF BONE AND MINERAL METABOLISM, 2019, 37 (04) : 668 - 675
  • [27] The effect of testosterone itself and in combination with letrozole on bone mineral density in male rats
    Forough Saki
    Seyed Reza Kasaee
    Faezeh Sadeghian
    Pedram Talezadeh
    Gholam Hossein Ranjbar Omrani
    Journal of Bone and Mineral Metabolism, 2019, 37 : 668 - 675
  • [28] Effect of Pig Skin Gelatin Hydrolysates on the Bone Mineral Density of Ovariectomized Rats
    Park, Jeong-Eun
    Ham, Jun-Sang
    Kim, Hey-Kyung
    Lee, Chi-Ho
    Kim, Dong-Wook
    Seol, Kuk-Hwan
    Oh, Mi-Hwa
    Kim, Dong-Hun
    Jang, Aera
    KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, 2012, 32 (02) : 234 - 240
  • [29] Influence of electromagnetic fields and protective effect of CAPE on bone mineral density in rats
    Yildiz, Mustafa
    Cicek, Ekrern
    Cerci, Sevim Sureyya
    Cerci, Celal
    Oral, Baha
    Koyu, Ahmet
    ARCHIVES OF MEDICAL RESEARCH, 2006, 37 (07) : 818 - 821
  • [30] The effect of prolactin itself and in combination with estrogen on bone mineral density in female rats
    Saki, Forough
    Sadeghian, Faezeh
    Kasaee, Seyed Reza
    Talezadeh, Pedram
    Omrani, Gholam Hossein Ranjbar
    GYNECOLOGICAL ENDOCRINOLOGY, 2019, 35 (06) : 539 - 543
12345