Effect of homocysteine on bone mineral density of rats

被引：8
|
作者：
Soyupek, Feray [1 ]
Cerci, Sureyya
Yidiz, Sedat
Yildiz, Mustafa
Gurnus, Burcin
机构：
[1] Suleyman Demirel Univ, Sch Med, Dept Phys Med & Rehabil, TR-32260 Isparta, Turkey
[2] Suleyman Demirel Univ, Sch Med, Dept Nucl Med, Isparta, Turkey
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2007年 / 118卷 / 03期
关键词：
homocysteine; bone; mineral density; rats; methionine;
D O I：
10.1007/s12011-007-0034-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) L-methionine the mean plasma levels of Hey were 7.67+/-1.25 and 61.2+/-11.4 mu mol/l, respectively. Only rats treated with the higher dose had Hey levels significantly higher than those of controls, 6.38+/-0.90 mu mol/l (p<0.001). Dual Energy X-ray Absotptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hey (p<0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.
引用
收藏
页码：255 / 259
页数：5
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