Effect of homocysteine on bone mineral density of rats

被引：8
|
作者：
Soyupek, Feray [1 ]
Cerci, Sureyya
Yidiz, Sedat
Yildiz, Mustafa
Gurnus, Burcin
机构：
[1] Suleyman Demirel Univ, Sch Med, Dept Phys Med & Rehabil, TR-32260 Isparta, Turkey
[2] Suleyman Demirel Univ, Sch Med, Dept Nucl Med, Isparta, Turkey
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2007年 / 118卷 / 03期
关键词：
homocysteine; bone; mineral density; rats; methionine;
D O I：
10.1007/s12011-007-0034-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg(-1) day(-1) L-methionine the mean plasma levels of Hey were 7.67+/-1.25 and 61.2+/-11.4 mu mol/l, respectively. Only rats treated with the higher dose had Hey levels significantly higher than those of controls, 6.38+/-0.90 mu mol/l (p<0.001). Dual Energy X-ray Absotptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hey (p<0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.
引用
收藏
页码：255 / 259
页数：5
相关论文
共 50 条
  • [1] Effect of Homocysteine on Bone Mineral Density of Rats
    Feray Soyupek
    Sureyya Cerci
    Sedat Yildiz
    Mustafa Yildiz
    Burcin Gumus
    Biological Trace Element Research, 2007, 118 : 255 - 259
  • [2] Effect of Melatonin on Bone Mineral Density of Irradiated Rats
    Orbak, Zerrin
    Ertekin, Vecdi
    Yildirim, Mustafa
    Ertekin, Vildan
    Seven, Bedri
    Karslioglu, Ihsan
    YAKHTEH, 2011, 12 (04): : 459 - 462
  • [3] Effect of Taurine Feeding on Bone Mineral Density and Bone Markers in Rats
    Choi, Mi-Ja
    Seo, Ji-Na
    TAURINE 8, VOL 2: NUTRITION AND METABOLISM, PROTECTIVE ROLE, AND ROLE IN REPRODUCTION, DEVELOPMENT, AND DIFFERENTIATION, 2013, 776 : 51 - 58
  • [4] Effect of Calcitriol on Bone Mineral Density and Bone Metabolism in Osteoporotic Rats
    Liu, Haipeng
    Jiao, Xubin
    Li, Xiangqing
    Xu, Xinru
    PAKISTAN JOURNAL OF ZOOLOGY, 2022, 54 (04) : 1939 - 1942
  • [5] HOMOCYSTEINE AND BONE MINERAL DENSITY IN VEGETARIANS AND ADULT WOMEN
    Satalic, Z.
    Baric, I. Colic
    Cecic, I.
    Keser, I.
    Cvijetic, S.
    Zizic, V.
    OSTEOPOROSIS INTERNATIONAL, 2009, 20 : 150 - 150
  • [6] Plasma total homocysteine level and bone mineral density - The Hordaland homocysteine study
    Gjesdal, CG
    Vollset, SE
    Ueland, PM
    Refsum, H
    Drevon, CA
    Gjessing, HK
    Tell, GS
    ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (01) : 88 - 94
  • [7] Effect of alendronate administration on bone mineral density and bone strength in castrated rats
    Broulik, PD
    Rosenkrancová, J
    Ruzicka, P
    Sedlácek, R
    HORMONE AND METABOLIC RESEARCH, 2005, 37 (07) : 414 - 418
  • [8] Effect of antidepressants on bone mineral density and bone metabolism in ovariectomized depressed rats
    Liu, Chao
    Liang, Chao
    Wang, Yiming
    Huang, Jie
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2024, 23 (04) : 683 - 689
  • [9] Cysteine, homocysteine and bone mineral density: A role for body composition?
    Elshorbagy, Amany K.
    Gjesdal, Clara Gram
    Nurk, Eha
    Tell, Grethe S.
    Ueland, Per M.
    Nygard, Ottar
    Tverdal, Aage
    Vollset, Stein E.
    Smith, A. David
    Refsum, Helga
    BONE, 2009, 44 (05) : 954 - 958
  • [10] ASSOCIATION OF HOMOCYSTEINE WITH BONE MINERAL DENSITY IN RHEUMATOID ARTHRITIS PATIENTS
    Alvarez de Cienfuegos, Antonio
    Cantero-Nieto, Lucia
    Alberto Garcia-Gomez, Jose
    Luis Callejas-Rubio, Jose
    Gonzalez-Gay, Miguel A.
    Ortego, Norberto
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 1607 - 1607
12345