Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

被引：4
|
作者：
Rubinson, M. A. [1 ]
Parkinson, J. A. [2 ]
Evstigneev, M. P. [1 ,3 ]
机构：
[1] Sevastopol State Univ, Dept Phys, Sevastopol 299053, Russia
[2] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland
[3] Belgorod State Univ, Dept Biol & Chem, Belgorod 308015, Russia
来源：
CHEMICAL PHYSICS LETTERS | 2015年 / 624卷
关键词：
MINOR-GROOVE; MOLECULAR RECOGNITION; SELF-ASSOCIATION; INTERCALATION;
D O I：
10.1016/j.cplett.2015.02.006
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 14
页数：3
相关论文
共 50 条
  • [1] Phosphorylation Regulation on the Homo-Dimeric Binding of Transactive Response DNA-Binding Protein
    Dong, Wanqian
    Zhou, Rui
    Chen, Jiawen
    Shu, Zhengyu
    Duan, Mojie
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 62 (21) : 5267 - 5275
  • [2] A thermodynamic signature for drug-DNA binding mode
    Chaires, Jonathan B.
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 453 (01) : 26 - 31
  • [3] Elucidation of drug-DNA intercalation binding mode
    Kumar, Mohan
    Chaurasia, Madhuri
    Mahendru, Swati
    Maurya, Jitendra Kumar
    CURRENT SCIENCE, 2014, 107 (06): : 954 - 955
  • [4] MECHANISM OF INHIBITION OF DNA GYRASE BY QUINOLONE ANTIBACTERIALS - A COOPERATIVE DRUG-DNA BINDING MODEL
    SHEN, LL
    MITSCHER, LA
    SHARMA, PN
    ODONNELL, TJ
    CHU, DWT
    COOPER, CS
    ROSEN, T
    PERNET, AG
    BIOCHEMISTRY, 1989, 28 (09) : 3886 - 3894
  • [5] MECHANISM OF INHIBITION OF DNA GYRASE BY QUINOLONE ANTIBACTERIALS - A COOPERATIVE DRUG-DNA BINDING MODEL
    SHEN, LL
    BARANOWSKI, J
    WAI, T
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, : 203 - 203
  • [6] Analysis of drug-DNA binding data
    Qu, XG
    Chaires, JB
    NUMERICAL COMPUTER METHODS, PART C, 2000, 321 : 353 - 369
  • [7] Drug-DNA recognition: energetics and implications for design
    Haq, I
    Ladbury, J
    JOURNAL OF MOLECULAR RECOGNITION, 2000, 13 (04) : 188 - 197
  • [8] SOLVATION EFFECTS AND THE MECHANISM OF DRUG-DNA BINDING
    BALDINI, G
    VARANI, G
    BIOCHEMICAL PHARMACOLOGY, 1988, 37 (09) : 1825 - 1826
  • [9] Thymol and carvacrol binding to DNA: Model for drug-DNA interaction
    Nafisi, S
    Hajiakhoondi, A
    Yektadoost, A
    BIOPOLYMERS, 2004, 74 (05) : 345 - 351
  • [10] Mechanisms of drug-DNA recognition distinguished by Raman spectroscopy
    Benevides, James M.
    Kawakami, Jessica
    Thomas, George J., Jr.
    JOURNAL OF RAMAN SPECTROSCOPY, 2008, 39 (11) : 1627 - 1634
12345