Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

被引：4
|
作者：
Rubinson, M. A. [1 ]
Parkinson, J. A. [2 ]
Evstigneev, M. P. [1 ,3 ]
机构：
[1] Sevastopol State Univ, Dept Phys, Sevastopol 299053, Russia
[2] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland
[3] Belgorod State Univ, Dept Biol & Chem, Belgorod 308015, Russia
来源：
CHEMICAL PHYSICS LETTERS | 2015年 / 624卷
关键词：
MINOR-GROOVE; MOLECULAR RECOGNITION; SELF-ASSOCIATION; INTERCALATION;
D O I：
10.1016/j.cplett.2015.02.006
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 14
页数：3
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