Entropic binding mode preference in cooperative homo-dimeric drug-DNA recognition

被引：4
|
作者：
Rubinson, M. A. [1 ]
Parkinson, J. A. [2 ]
Evstigneev, M. P. [1 ,3 ]
机构：
[1] Sevastopol State Univ, Dept Phys, Sevastopol 299053, Russia
[2] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland
[3] Belgorod State Univ, Dept Biol & Chem, Belgorod 308015, Russia
来源：
CHEMICAL PHYSICS LETTERS | 2015年 / 624卷
关键词：
MINOR-GROOVE; MOLECULAR RECOGNITION; SELF-ASSOCIATION; INTERCALATION;
D O I：
10.1016/j.cplett.2015.02.006
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The present work reveals the entropic preference in the two-step binding process of small molecule DNA minor groove binders (MGBs), involving the formation of a dimer in free solution followed by the binding of that dimer to DNA, which contrasts with the sequential or simultaneous cooperative binding of two unbound MGB molecules with DNA that is implicitly assumed in the majority of reported DNA-MGB binding studies. The results are generalized for the n-mer binding case and the methodological outcomes are discussed. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 14
页数：3
相关论文
共 50 条
  • [31] Exploring the Strength, Mode, Dynamics, and Kinetics of Binding Interaction of a Cationic Biological Photosensitizer with DNA: Implication on Dissociation of the Drug-DNA Complex via Detergent Sequestration
    Paul, Bijan Kumar
    Guchhait, Nikhil
    JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (41): : 11938 - 11949
  • [32] Influence of oxidative stress on drug-DNA binding: Microcalorimetric and mechanistic insights with anticancer drugs
    Mukhija, Achal
    JOURNAL OF MOLECULAR LIQUIDS, 2022, 368
  • [33] Molecular aspects on the interaction of phenosafranine to deoxyribonucleic acid: Model for intercalative drug-DNA binding
    Das, Suman
    Kumar, Gopinatha Suresh
    JOURNAL OF MOLECULAR STRUCTURE, 2008, 872 (01) : 56 - 63
  • [34] A bZip transcription factor with homo/heterodimer-induced DNA-binding preference
    Wilmanns, Matthias
    Consani-Textor, Larissa
    Pogenberg, Vivian
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2013, 69 : S71 - S71
  • [35] DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes
    Roeland Boer, D.
    Canals, Albert
    Coll, Miquel
    DALTON TRANSACTIONS, 2009, (03) : 399 - 414
  • [36] Isohelicity and phasing in drug-DNA sequence recognition: Crystal structure of a tris(benzimidazole)-oligonucleotide complex
    Clark, GR
    Gray, EJ
    Neidle, S
    Li, YH
    Leupin, W
    BIOCHEMISTRY, 1996, 35 (43) : 13745 - 13752
  • [37] Cooperative binding of distamyoin-A to DNA in the 2:1 mode
    Fagan, Patricia
    Wemmer, David E.
    Journal of the American Chemical Society, 1992, 114 (03):
  • [38] Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction
    Beniaminov, Artemy D.
    Chashchina, Galina, V
    Livshits, Mikhail A.
    Kechko, Olga, I
    Mitkevich, Vladimir A.
    Mamaeva, Olga K.
    Tevyashova, Anna N.
    Shtil, Alexander A.
    Shchyolkina, Anna K.
    Kaluzhny, Dmitry N.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (15) : 1 - 14
  • [39] CALORIMETRIC AND SPECTROSCOPIC INVESTIGATION OF DRUG-DNA INTERACTIONS .1. THE BINDING OF NETROPSIN TO POLY D(AT)
    MARKY, LA
    BLUMENFELD, KS
    BRESLAUER, KJ
    NUCLEIC ACIDS RESEARCH, 1983, 11 (09) : 2857 - 2870
  • [40] Daunomycin binding to detergent micelles: A model system for evaluating the hydrophobic contribution to drug-DNA interactions
    Dignam, John David
    Qu, Xiaogang
    Ren, Jinsong
    Chaires, Jonathan B.
    JOURNAL OF PHYSICAL CHEMISTRY B, 2007, 111 (39): : 11576 - 11584
12345