Addition of water to zinc triflate promotes a novel reaction: Stereoselective Mannich-type reaction of chiral aldimines with 2-silyloxybutadienes

被引：18
|
作者：
Ishimaru, K [1 ]
Kojima, T [1 ]
机构：
[1] Natl Def Acad, Dept Chem, Yokosuka, Kanagawa 2398686, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 12期
关键词：
D O I：
10.1021/jo0300338
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel stereoselective Mannich-type reaction of chiral aldimines with 2-silyloxybutadienes in the presence of zinc triflate and water has been achieved. The diastereoselectivities of the products were 74-90% de, and no cycloadducts were detected. Classical Mannich-type products were also obtained by using zinc triflate and water with high diastereoselectivities.
引用
收藏
页码：4959 / 4962
页数：4
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