Synthesis of β-amino esters by bismuth triflate catalyzed three-component Mannich-type reaction

被引：41
|
作者：
Ollevier, T [1 ]
Nadeau, E [1 ]
机构：
[1] Univ Laval, Dept Chim, Quebec City, PQ G1K 7P4, Canada
来源：
SYNLETT | 2006年 / 02期
关键词：
amino esters; bismuth; green chemistry; Mannich-type reaction; multicomponent reactions (MCR); silyl enolates;
D O I：
10.1055/s-2005-923594
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed an efficient, bismuth-catalyzed, Mannich-type three-component reaction by combining the corresponding aldehyde, amine, and silyl ketene acetal. The reaction proceeds rapidly and affords the corresponding beta-amino esters in high yields (up to 90%).
引用
收藏
页码：219 / 222
页数：4
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