Synthesis and antitumor cytotoxicity evaluation of novel thiazole-containing glycosylated Polyamides

被引：6
|
作者：
Kumar, R [1 ]
Lown, JW [1 ]
机构：
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 24期
关键词：
amides; antitumor agents; DNA; synthetic methods;
D O I：
10.1002/ejoc.200300532
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Certain thiazole-containing water-soluble glycosylated polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCl against three types of cancer-cells. Glycosyl moieties were introduced onto the polyamide backbone in order to increase the water-solubility of the longer polymers. This necessitated the development of novel synthetic methods. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
引用
收藏
页码：4842 / 4851
页数：10
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