Synthesis and antitumor cytotoxicity evaluation of novel thiazole-containing glycosylated Polyamides

被引：6

作者：

Kumar, R ^{[1
]}

Lown, JW ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 24期

关键词：

amides; antitumor agents; DNA; synthetic methods;

D O I：

10.1002/ejoc.200300532

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Certain thiazole-containing water-soluble glycosylated polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCl against three types of cancer-cells. Glycosyl moieties were introduced onto the polyamide backbone in order to increase the water-solubility of the longer polymers. This necessitated the development of novel synthetic methods. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

引用

页码：4842 / 4851

页数：10

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