Synthesis and antitumor cytotoxicity evaluation of novel thiazole-containing glycosylated Polyamides

被引：6
|
作者：
Kumar, R [1 ]
Lown, JW [1 ]
机构：
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 24期
关键词：
amides; antitumor agents; DNA; synthetic methods;
D O I：
10.1002/ejoc.200300532
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Certain thiazole-containing water-soluble glycosylated polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCl against three types of cancer-cells. Glycosyl moieties were introduced onto the polyamide backbone in order to increase the water-solubility of the longer polymers. This necessitated the development of novel synthetic methods. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
引用
收藏
页码：4842 / 4851
页数：10
相关论文
共 50 条
  • [31] Studies toward the Total Synthesis of Epothilone D: Synthesis of the Thiazole-Containing Northern Segment
    Suzuki, Momoko
    Hashimoto, Shougo
    Sakamoto, Shun
    Kogen, Hiroshi
    Kobayashi, Kenichi
    NATURAL PRODUCT COMMUNICATIONS, 2019, 14 (09)
  • [32] Aeruginazole A, a Novel Thiazole-Containing Cyclopeptide from the Cyanobacterium Microcystis sp.
    Raveh, Avi
    Carmeli, Shmuel
    ORGANIC LETTERS, 2010, 12 (15) : 3536 - 3539
  • [33] Novel Endoperoxide Steroid Derivatives Containing Thiazole Moiety as Potential Antitumor Agents: Design, Synthesis, and Cytotoxic Evaluation
    Li, Gang
    Guo, Xiaoshan
    Ren, Wenkang
    Wang, Jiafeng
    Lv, Zhen
    Li, Hongling
    Sun, Mingrui
    Li, Xiaoming
    Chen, Gang
    Zhang, Zhiguo
    Zhang, Wenting
    Bu, Ming
    NATURAL PRODUCT COMMUNICATIONS, 2023, 18 (05)
  • [34] Synthesis and characterization of thiazole-containing chromophores for second-order nonlinear optics
    Wang, YK
    Shu, CF
    Breitung, EM
    McMahon, RJ
    JOURNAL OF MATERIALS CHEMISTRY, 1999, 9 (07) : 1449 - 1452
  • [35] Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives
    Pinto Braga, Saulo Feheiberg
    Fonseca, Nayara Cristina
    Ramos, Jonas Pereira
    de Souza-Fagundes, Elaine Maria
    de Oliveira, Renata Barbosa
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 52 (02) : 299 - 307
  • [36] Novel thiazole-containing complexing agents and luminescence of their europium(III) and terbium(III) chelates
    Mukkala, VM
    Liitti, P
    Hemmila, I
    Takalo, H
    Matachescu, C
    Kankare, J
    HELVETICA CHIMICA ACTA, 1996, 79 (01) : 295 - 306
  • [37] Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole-Containing Triazoles as Antibacterials
    Santosh, Rangappa
    Selvam, Mukunthan K.
    Kanekar, Saptami U.
    Nagaraja, Gundibasappa K.
    Kumar, Madan
    CHEMISTRYSELECT, 2018, 3 (14): : 3892 - 3898
  • [38] Thiazole Containing Nitrogen Mustards: Synthesis, Structural Evaluation, Cytotoxicity and DNA Binding Studies
    Raghavendra, Nulgulmnalli Manjunathiah
    Renuka, Surampudi
    Gupta, Sayan Dutta
    Divya, Pingili
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (09) : 838 - 842
  • [39] Two-Step Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole-Containing Cyclopeptides
    Nefzi, Adel
    Arutyunyan, Sergey
    Fenwick, Jason E.
    JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (22): : 7939 - 7941
  • [40] Synthesis of water soluble cyclotriphosphazenes with thiazole-containing side groups: Amphiphilic and hydrolytic degradable
    Uslu, Aylin
    Ozcan, Elif
    POLYHEDRON, 2018, 148 : 49 - 54
12345