Enhancing brown fat with NFIA

被引：3
|
作者：
Shapira, Suzanne N. [1 ]
Seale, Patrick [1 ]
机构：
[1] Univ Penn, Inst Diabet Obes & Metab, Dept Cell & Dev Biol, Smilow Ctr Translat Res,Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 09期
关键词：
ADIPOSE-TISSUE; GENE-EXPRESSION; TRANSCRIPTION;
D O I：
10.1038/ncb3591
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
引用
收藏
页码：1006 / 1007
页数：2
相关论文
共 50 条
  • [41] THE ENERGETICS OF BROWN FAT IN MAN
    LESLIE, P
    CUNNINGHAM, S
    JUNG, RT
    NICHOLLS, D
    SCOTTISH MEDICAL JOURNAL, 1985, 30 (01) : 57 - 57
  • [42] Cidea, brown fat and obesity
    Peng, L
    MECHANISMS OF AGEING AND DEVELOPMENT, 2004, 125 (04) : 337 - 338
  • [43] IMMUNOSUPPRESSION BY EXTRACTS OF BROWN FAT
    SIDKY, YA
    HAYWARD, JS
    FEDERATION PROCEEDINGS, 1972, 31 (02) : A800 - &
  • [44] HIBERNOMAS, BROWN FAT TUMORS
    NOVY, FG
    WILSON, JW
    ARCHIVES OF DERMATOLOGY, 1956, 73 (02) : 149 - 157
  • [45] LOCALIZATION OF CATECHOLAMINES IN BROWN FAT
    DAWKINS, MJR
    DUCKETT, S
    PEARSE, AGE
    NATURE, 1966, 209 (5028) : 1144 - &
  • [46] Tracing human brown fat
    Mariëtte R Boon
    Emmani B M Nascimento
    Wouter D van Marken Lichtenbelt
    Nature Medicine, 2015, 21 : 667 - 668
  • [47] Restoring brown fat commitment
    Andrea Du Toit
    Nature Reviews Molecular Cell Biology, 2016, 17 : 204 - 204
  • [48] HIBERNOMA - A TUMOR OF BROWN FAT
    SUTHERLAND, JC
    CALLAHAN, WP
    CAMPBELL, GL
    CANCER, 1952, 5 (02) : 364 - 368
  • [49] THE BROWN FAT-CELL
    NEDERGAARD, J
    LINDBERG, O
    INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1982, 74 : 187 - 286
  • [50] EFFECT OF TSH ON BROWN FAT
    BURTON, PA
    LANCET, 1975, 2 (7933): : 505 - 505
12345