Enhancing brown fat with NFIA

被引：3
|
作者：
Shapira, Suzanne N. [1 ]
Seale, Patrick [1 ]
机构：
[1] Univ Penn, Inst Diabet Obes & Metab, Dept Cell & Dev Biol, Smilow Ctr Translat Res,Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 09期
关键词：
ADIPOSE-TISSUE; GENE-EXPRESSION; TRANSCRIPTION;
D O I：
10.1038/ncb3591
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
引用
收藏
页码：1006 / 1007
页数：2
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